Journal ArticleDOI
miR-425-5p as an exosomal biomarker for metastatic prostate cancer
Michele Patrícia Rode,Adny Henrique Silva,Julia Cisilotto,Daiane Rosolen,Tânia Beatriz Creczynski-Pasa +4 more
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TLDR
In this paper, the expression profile of exosomal microRNAs (miRNAs) derived from metastatic prostate cancer (mPCa) cell lines (LNCaP and PC-3) was evaluated by miRNA microarray analysis.About:
This article is published in Cellular Signalling.The article was published on 2021-11-01. It has received 13 citations till now. The article focuses on the topics: Prostate cancer & LNCaP.read more
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Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
K. Preethi,Sushmaa Chandralekha Selvakumar,K Rossi,Selvaraj Jayaraman,Deusdedit Tusubira,Durairaj Sekar +5 more
TL;DR: In this paper , a review of exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers is presented. But the authors focus on the use of liquid biopsies as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation.
Journal ArticleDOI
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
K. Preethi,Sushmaa Chandralekha Selvakumar,K Rossi,Selvaraj Jayaraman,Deusdedit Tusubira,Durairaj Sekar +5 more
TL;DR: In this paper , a review of exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers is presented. But the authors focus on the use of liquid biopsies as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation.
Journal ArticleDOI
Molecular Biomarkers in Cancer
TL;DR: Improvement in the field of cancer biomarkers is, however, needed to overcome the scientific challenge of developing new biomarkers with greater sensitivity, specificity, and positive predictive value.
Journal ArticleDOI
Identification of Diagnostic Markers for Breast Cancer Based on Differential Gene Expression and Pathway Network
TL;DR: It is shown that the difference of gene expression level is important for the diagnosis of breast cancer, and 23 breast cancer diagnostic markers are identified, which provides valuable information for clinical diagnosis and basic treatment experiments.
Journal ArticleDOI
Pro-angiogenic effect of PC-3 exosomes in endothelial cells in vitro.
Anne Natalie Prigol,Michele Patrícia Rode,Adny Henrique Silva,Julia Cisilotto,Tânia Beatriz Creczynski-Pasa +4 more
TL;DR: In this article, the angiogenic potential of exosomes released from Pca cell lines with distinctive profiles of androgen response through exosome isolation, microscopy and uptake, functional assays follow up by microarray, RT-qPCR and bioinformatics analysis.
References
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Journal ArticleDOI
Prediction of metastatic prostate cancer by prostate-specific antigen in combination with T stage and Gleason Grade: Nationwide, population-based register study.
Frederik Birkebæk Thomsen,Marcus Westerberg,Marcus Westerberg,Hans Garmo,Hans Garmo,David Robinson,Lars Holmberg,Hans David Ulmert,Pär Stattin +8 more
TL;DR: Results support the use of imaging to confirm bone metastases in men with advanced prostate cancer as no PSA level in combination with T stage and GGG could accurately rule in metastatic prostate cancer and thereby safely omit bone imaging.
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MicroRNA-425-5p promotes the development of prostate cancer via targeting forkhead box J3.
TL;DR: Taken together, the results demonstrated miR-425-5p may contribute the malignancy progression of PCa in a mechanism involving FOXJ3, implicating miR -425- 5p may be developed as therapeutic target forPCa in the future.
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EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis
TL;DR: In this article, the authors found that EWI-2 localized on both the cell membrane and exosomes regulates the distribution of miR-3934-5p between cells and exo-somes.
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Inhibition of cancer cell-derived exosomal microRNA-183 suppresses cell growth and metastasis in prostate cancer by upregulating TPM1
Yanping Dai,Xiaoqin Gao +1 more
TL;DR: In this article, the effect of exosomal miR-183 on prostate cancer cell proliferation, invasion and migration was evaluated using in vitro gain-and loss-of-function experiments.
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Overexpression of miR-425-5p is associated with poor prognosis and tumor progression in non-small cell lung cancer.
TL;DR: Overexpression of miR-425-5p predicts poor prognosis of NSCLC and promotes cancer cell proliferation, migration and invasion by targeting FOXJ3.