Journal ArticleDOI
miR-425-5p as an exosomal biomarker for metastatic prostate cancer
Michele Patrícia Rode,Adny Henrique Silva,Julia Cisilotto,Daiane Rosolen,Tânia Beatriz Creczynski-Pasa +4 more
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TLDR
In this paper, the expression profile of exosomal microRNAs (miRNAs) derived from metastatic prostate cancer (mPCa) cell lines (LNCaP and PC-3) was evaluated by miRNA microarray analysis.About:
This article is published in Cellular Signalling.The article was published on 2021-11-01. It has received 13 citations till now. The article focuses on the topics: Prostate cancer & LNCaP.read more
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Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
K. Preethi,Sushmaa Chandralekha Selvakumar,K Rossi,Selvaraj Jayaraman,Deusdedit Tusubira,Durairaj Sekar +5 more
TL;DR: In this paper , a review of exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers is presented. But the authors focus on the use of liquid biopsies as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation.
Journal ArticleDOI
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
K. Preethi,Sushmaa Chandralekha Selvakumar,K Rossi,Selvaraj Jayaraman,Deusdedit Tusubira,Durairaj Sekar +5 more
TL;DR: In this paper , a review of exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers is presented. But the authors focus on the use of liquid biopsies as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation.
Journal ArticleDOI
Molecular Biomarkers in Cancer
TL;DR: Improvement in the field of cancer biomarkers is, however, needed to overcome the scientific challenge of developing new biomarkers with greater sensitivity, specificity, and positive predictive value.
Journal ArticleDOI
Identification of Diagnostic Markers for Breast Cancer Based on Differential Gene Expression and Pathway Network
TL;DR: It is shown that the difference of gene expression level is important for the diagnosis of breast cancer, and 23 breast cancer diagnostic markers are identified, which provides valuable information for clinical diagnosis and basic treatment experiments.
Journal ArticleDOI
Pro-angiogenic effect of PC-3 exosomes in endothelial cells in vitro.
Anne Natalie Prigol,Michele Patrícia Rode,Adny Henrique Silva,Julia Cisilotto,Tânia Beatriz Creczynski-Pasa +4 more
TL;DR: In this article, the angiogenic potential of exosomes released from Pca cell lines with distinctive profiles of androgen response through exosome isolation, microscopy and uptake, functional assays follow up by microarray, RT-qPCR and bioinformatics analysis.
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Journal ArticleDOI
Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine
Jacob Fredsøe,Anne K.I. Rasmussen,Anni R. Thomsen,Peter Mouritzen,Søren Høyer,Michael Borre,Torben F. Ørntoft,Karina Dalsgaard Sørensen +7 more
TL;DR: Two new sets of microRNA biomarkers in urine that could accurately predict the presence of prostate cancer and the likelihood of recurrence after radical prostatectomy are found.
Journal ArticleDOI
miR-21-5p, miR-141-3p, and miR-205-5p levels in urine-promising biomarkers for the identification of prostate and bladder cancer.
Nassim Ghorbanmehr,Sedigheh Gharbi,Eberhard Korsching,Mahmood Tavallaei,Behzad Einollahi,Seyed Javad Mowla +5 more
TL;DR: The objective is to identify microRNAs as biomarkers in urine samples of bladder and prostate cancers to improve the existing diagnostic methods in this field.
Journal Article
TP53 gene mutations in prostate cancer progression.
Thorsten H. Ecke,Horst Schlechte,Katrin Schiemenz,Markus D. Sachs,Severin V. Lenk,Birgit Rudolph,Stefan A. Loening +6 more
TL;DR: TP53 mutations in exon 7 and exon 8 are factors of tumor progression in PCa and their contribution to tumor recurrence is more significant than tumor stage and pretherapeutic PSA level.
Journal ArticleDOI
Exosome-derived microRNAs contribute to prostate cancer chemoresistance
Jing Li,Xin Yang,Hao Guan,Atsushi Mizokami,Evan T. Keller,Xiaozhen Xu,Xia Liu,Jiyong Tan,Longyuan Hu,Yi Lu,Jian Zhang +10 more
TL;DR: The enrichment results of deregulated miRNAs and known target genes showed that a few pathways were correlated with several critical cell signaling pathways, which may provide a linkage between PCa chemoresistance and exosome regulatory networks and thus lead to propose that AR, PTEN and TCF4 genes may be the important genes which are regulated by exosomes in chemores resistance cancer cells.
Journal ArticleDOI
Novel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profiling.
Helle Kristensen,Anni R. Thomsen,Christa Haldrup,Lars Dyrskjøt,Søren Høyer,Michael Borre,Peter Mouritzen,Torben F. Ørntoft,Karina Dalsgaard Sørensen +8 more
TL;DR: This is the first report of a miRNA signature with significant independent prognostic value demonstrated in three PC patient cohorts, and a new 3-miRNA prognostic classifier is trained.