Journal ArticleDOI
miR-425-5p as an exosomal biomarker for metastatic prostate cancer
Michele Patrícia Rode,Adny Henrique Silva,Julia Cisilotto,Daiane Rosolen,Tânia Beatriz Creczynski-Pasa +4 more
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TLDR
In this paper, the expression profile of exosomal microRNAs (miRNAs) derived from metastatic prostate cancer (mPCa) cell lines (LNCaP and PC-3) was evaluated by miRNA microarray analysis.About:
This article is published in Cellular Signalling.The article was published on 2021-11-01. It has received 13 citations till now. The article focuses on the topics: Prostate cancer & LNCaP.read more
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Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
K. Preethi,Sushmaa Chandralekha Selvakumar,K Rossi,Selvaraj Jayaraman,Deusdedit Tusubira,Durairaj Sekar +5 more
TL;DR: In this paper , a review of exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers is presented. But the authors focus on the use of liquid biopsies as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation.
Journal ArticleDOI
Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
K. Preethi,Sushmaa Chandralekha Selvakumar,K Rossi,Selvaraj Jayaraman,Deusdedit Tusubira,Durairaj Sekar +5 more
TL;DR: In this paper , a review of exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers is presented. But the authors focus on the use of liquid biopsies as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation.
Journal ArticleDOI
Molecular Biomarkers in Cancer
TL;DR: Improvement in the field of cancer biomarkers is, however, needed to overcome the scientific challenge of developing new biomarkers with greater sensitivity, specificity, and positive predictive value.
Journal ArticleDOI
Identification of Diagnostic Markers for Breast Cancer Based on Differential Gene Expression and Pathway Network
TL;DR: It is shown that the difference of gene expression level is important for the diagnosis of breast cancer, and 23 breast cancer diagnostic markers are identified, which provides valuable information for clinical diagnosis and basic treatment experiments.
Journal ArticleDOI
Pro-angiogenic effect of PC-3 exosomes in endothelial cells in vitro.
Anne Natalie Prigol,Michele Patrícia Rode,Adny Henrique Silva,Julia Cisilotto,Tânia Beatriz Creczynski-Pasa +4 more
TL;DR: In this article, the angiogenic potential of exosomes released from Pca cell lines with distinctive profiles of androgen response through exosome isolation, microscopy and uptake, functional assays follow up by microarray, RT-qPCR and bioinformatics analysis.
References
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Journal ArticleDOI
LinkedOmics: analyzing multi-omics data within and across 32 cancer types.
TL;DR: It is demonstrated that LinkedOmics provides a unique platform for biologists and clinicians to access, analyze and compare cancer multi-omics data within and across tumor types.
Journal ArticleDOI
Progress in Exosome Isolation Techniques.
TL;DR: An overview of exosome isolation techniques is provided, opening up new perspectives towards the development more innovative strategies and devices for more time saving, cost effective, and efficient isolations ofExosomes from a wide range of biological matrices.
Journal ArticleDOI
Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
Marina Colombo,Catarina Moita,Guillaume van Niel,Guillaume van Niel,Joanna Kowal,Joanna Kowal,James Vigneron,James Vigneron,Philippe Benaroch,Philippe Benaroch,Nicolas Manel,Nicolas Manel,Luis F. Moita,Clotilde Théry,Clotilde Théry,Graça Raposo,Graça Raposo +16 more
TL;DR: The results reveal a role for selected ESCRT components and accessory proteins in exosome secretion and composition by HeLa-CIITA and highlight biogenetic differences in vesicles secreted by a tumour cell line and primary DCs.
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Changes in circulating microRNA levels associated with prostate cancer
Richard J. Bryant,Traci Pawlowski,James W.F. Catto,G Marsden,Robert L. Vessella,Brian Kent Rhees,C. Kuslich,Tapio Visakorpi,Freddie C. Hamdy +8 more
TL;DR: Observations suggest that changes in miR concentration in prostate cancer patients may be identified by analysing various body fluids, and circulating miRs may be used to diagnose and stage prostate cancer.
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Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis.
Nobuyoshi Kosaka,Haruhisa Iguchi,Keitaro Hagiwara,Yusuke Yoshioka,Fumitaka Takeshita,Takahiro Ochiya +5 more
TL;DR: It is demonstrated that the neutral sphyngomyelinase 2 (nSMase2) regulates exosomal microRNA (miRNA) secretion and promotes angiogenesis within the tumor microenvironment as well as metastasis, suggesting that the horizontal transfer of exosome miRNAs from cancer cells can dictate the microenviromental niche for the benefit of the cancer cell.