Liquid biopsy: Exosomal microRNAs as novel diagnostic and prognostic biomarkers in cancer
K. Preethi,Sushmaa Chandralekha Selvakumar,K Rossi,Selvaraj Jayaraman,Deusdedit Tusubira,Durairaj Sekar +5 more
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TLDR
In this paper , a review of exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers is presented. But the authors focus on the use of liquid biopsies as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation.Abstract:
Detecting cancer at an early stage before clinical manifestation could be an effective strategy to decrease cancer mortality. Thus, identifying liquid biopsy biomarkers with high efficacy could be a promising approach for non-invasive diagnosis of cancer.Liquid biopsies are increasingly used as a supplement to biopsy, as it enables disease progression to be detected months before clinical and radiographic confirmation. Many bodily fluids contain exosomal microRNAs (miRNAs) which could provide a new class of biomarkers for early and minimally invasive cancer diagnosis due to the stability of miRNAs in exosomes. In this review, we mainly focused on the exosomal miRNAs (liquid biopsy) as biomarkers in the diagnosis and prognosis of various cancers.Exosomal miRNAs can be used as diagnostic and prognosis biomarkers that provide unique insights and a more dynamic perspective of the progression and therapeutic responses in various malignancies. Therefore, the development of novel and more sensitive technologies that exploit exosomal miRNAs should be a priority for cancer management. read more
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miRNAs insights into rheumatoid arthritis: Favorable and detrimental aspects of key performers.
Ahmed S. Doghish,Ahmed Ismail,Hesham A. El-Mahdy,Samy Y. Elkhawaga,Elsayed G.E. Elsakka,E. A. Mady,Mahmoud Ahmed Elrebehy,Mahmoud A F Khalil,H. M. El-Husseiny +8 more
TL;DR: In this article , the role of miRNAs in RA diagnosis and prognosis has been discussed, and they are also applied as a choice for treatment based on their effects on the immune system and inflammatory cytokines.
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miRNAs as cornerstones in adipogenesis and obesity.
Samy Y. Elkhawaga,Ahmed Ismail,Elsayed G.E. Elsakka,Ahmed S. Doghish,Mohamed Amr Elkady,Hesham A. El-Mahdy +5 more
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Molecular Biomarkers in Cancer
TL;DR: Improvement in the field of cancer biomarkers is, however, needed to overcome the scientific challenge of developing new biomarkers with greater sensitivity, specificity, and positive predictive value.
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MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
TL;DR: In this paper , a review of the miRNAs involved in tumor metastasis by regulation of EMT-activating signaling pathways is presented, which can be used as diagnostic and therapeutic biomarkers.
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MicroRNAs as the critical regulators of cell migration and invasion in thyroid cancer
TL;DR: In this paper , a review of the miRNAs involved in tumor metastasis by regulation of EMT-activating signaling pathways is presented, which can be used as diagnostic and therapeutic biomarkers.
References
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