Journal ArticleDOI
Mitochondria defects are involved in lead-acetate-induced adult hematopoietic stem cell decline.
Jun Liu,Dao-Yong Jia,Shi-Zhong Cai,Cheng-Peng Li,Meng-Si Zhang,Yanyan Zhang,Chonghuai Yan,Yaping Wang +7 more
TLDR
Results indicate that lead acetate perturbs the hematopoietic balance of adult HSCs, associated with cellular mitochondria defects, increased intracellular ROS generation, and in vivo treatment with the antioxidant vitamin C led to reversion of the CD90(+)CD45(-) compartment functional decline.About:
This article is published in Toxicology Letters.The article was published on 2015-05-19. It has received 18 citations till now. The article focuses on the topics: Lead acetate & Stem cell.read more
Citations
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Journal ArticleDOI
Clinical and molecular aspects of lead toxicity: An update
TL;DR: The molecular basis of lead exposure resulting in various systemic effects is being extensively explored, and many genetic targets are identified, but their possible mechanisms are still an area to be explored.
Journal ArticleDOI
Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation.
TL;DR: This review focuses on a detailed overview of stem cell metabolism in vitro and defines the metabolic flux alterations in stem cells to shed light on stemness features and differentiation pathways that control the fate of stem cells.
Journal ArticleDOI
Vitamin D alleviates lead induced renal and testicular injuries by immunomodulatory and antioxidant mechanisms in rats.
Mohammad A. BaSalamah,Abdelghany H. Abdelghany,Mohamed El-Boshy,Jawwad Ahmad,Shakir Idris,Bassem Refaat +5 more
TL;DR: This report is the first to reveal potential protective effects for VD against Pb-induced renal and testicular injuries via anti-inflammatory and anti-oxidative mechanisms.
Journal ArticleDOI
Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach.
Sefa Kucukler,Fulya Benzer,Serkan Yildirim,Cihan Gur,Fatih Mehmet Kandemir,Aydın Şükrü Bengü,Adnan Ayna,Cuneyt Caglayan,Muhammet Bahaeddin Dortbudak +8 more
TL;DR: It was determined that chrysin (CR) decreases PbAc-induced lipid peroxidation due to its antioxidant properties and increases catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and glutATHione (GSH) levels.
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Reactive Oxygen Species and Nrf2: Functional and Transcriptional Regulators of Hematopoiesis.
TL;DR: The possibility of using small molecule antioxidants, such as N-acetyl cysteine, resveratrol, and curcumin, to augment HSC function and improve the therapeutic efficacy of BM transplantation is discussed.
References
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Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
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Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter
Richard L. Canfield,Charles R. Henderson,Deborah A. Cory-Slechta,Christopher Cox,Christopher Cox,Todd A. Jusko,Bruce P. Lanphear +6 more
TL;DR: Blood lead concentrations, even those below 10 microg per deciliter, are inversely associated with children's IQ scores at three and five years of age, and associated declines in IQ are greater at these concentrations than at higher concentrations.
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The role of senescent cells in ageing
TL;DR: A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
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Toxicity of lead: A review with recent updates.
TL;DR: A comprehensive account of recent updates describing health effects of lead exposure, relevant biomarkers and mechanisms involved in lead toxicity, and updates the readers about recent advances in chelation therapy and newer therapeutic strategies, like nanoencapsulation, to treat lead induced toxic manifestations are provided.
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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Keisuke Ito,Atsushi Hirao,Atsushi Hirao,Fumio Arai,Keiyo Takubo,Sahoko Matsuoka,Kana Miyamoto,Masako Ohmura,Masako Ohmura,Kazuhito Naka,Kentaro Hosokawa,Yasuo Ikeda,Toshio Suda +12 more
TL;DR: In this paper, the authors show that activation of p38 MAPK in response to increasing levels of reactive oxygen species (ROS) limits the lifespan of HSCs in vivo.