Metabolic regulation of mitochondrial dynamics
Prashant Mishra,David C. Chan +1 more
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TLDR
This work reviews the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.Abstract:
Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.read more
Citations
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AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig,Reuben J. Shaw +1 more
TL;DR: How AMPK functions as a central mediator of the cellular response to energetic stress and mitochondrial insults and coordinates multiple features of autophagy and mitochondrial biology is discussed.
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Mitochondria and Cancer
TL;DR: Evaluating mechanisms of mitochondrial function during tumorigenesis will be critical for the next generation of cancer therapeutics as multiple aspects of mitochondrial biology beyond bioenergetics support transformation.
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Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
Michael D. Buck,Michael D. Buck,David O’Sullivan,Ramon I. Klein Geltink,Jonathan D. Curtis,Chih-Hao Chang,David E. Sanin,Jing Qiu,Jing Qiu,Oliver Kretz,Oliver Kretz,Daniel Braas,Gerritje J.W. van der Windt,Qiongyu Chen,Stanley Ching-Cheng Huang,Christina M. O’Neill,Brian T. Edelson,Edward J. Pearce,Edward J. Pearce,Hiromi Sesaki,Tobias B. Huber,Tobias B. Huber,Angelika S. Rambold,Angelika S. Rambold,Erika L. Pearce +24 more
TL;DR: The data suggest that, by altering cristae morphology, fusion in TM cells configures electron transport chain (ETC) complex associations favoring oxidative phosphorylation (OXPHOS) and FAO, while fission in TE cells leads to cristsae expansion, reducing ETC efficiency and promoting aerobic glycolysis.
Journal ArticleDOI
Mitochondrial dynamics: overview of molecular mechanisms
TL;DR: An overview of the molecular mechanisms that govern mitochondrial fission and fusion in mammals is described and several members of the machinery can undergo post-translational modifications modulating these processes.
Journal ArticleDOI
Mitochondrial energetics in the kidney
TL;DR: Implementing compounds that stimulate mitochondrial biogenesis can restore mitochondrial and renal function in mouse models of AKI and diabetes mellitus and inhibiting the fission protein dynamin 1-like protein (DRP1) might ameliorate ischaemic renal injury by blocking mitochondrial fission.
References
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Derek P. Narendra,Seok Min Jin,Atsushi Tanaka,Der-Fen Suen,Clement A. Gautier,Jie Shen,Mark R. Cookson,Richard J. Youle +7 more
TL;DR: The authors suggest that PINK1 and Parkin form a pathway that senses damaged mitochondria and selectively targets them for degradation.
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
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