Journal ArticleDOI
Modulation of blood glucose by melatonin: a direct action on melatonin receptors in mouse hepatocytes.
TLDR
Melatonin receptors were studied in isolated mouse hepatocytes using the 2[125I]iodomelatonin binding assay, indicating that the binding was mediated by the ML1 receptor subtype and the linear Rosenthal plots, the close proximity of the Hill coefficient to unity and the monophasic competition curves suggest that a single class of 2[ 125I?]iodomelsatonin binding sites is present in the mouse hepatocyte.Abstract:
Melatonin receptors were studied in isolated mouse hepatocytes using the 2[125I]iodomelatonin binding assay. The binding of 2[125I]iodomelatonin to hepatocytes isolated from theread more
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Journal ArticleDOI
Melatonin in type 2 diabetes mellitus and obesity
Angeliki Karamitri,Angeliki Karamitri,Angeliki Karamitri,Ralf Jockers,Ralf Jockers,Ralf Jockers +5 more
TL;DR: The rs10830963 single-nucleotide polymorphism (SNP) in the MTNR1B locus is associated with increased fasting plasma glucose levels and impaired insulin secretion, as well as increased risk of type 2 diabetes mellitus (T2DM) and gestational Diabetes mellitus.
Journal ArticleDOI
Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon.
TL;DR: The study of melatonin–insulin interactions in diabetic rat models has revealed an inverse relationship: an increase in melatonin levels leads to a down-regulation of insulin secretion and vice versa; elucidation of the possible inverse interrelationship in man may open new avenues in the therapy of diabetes.
Journal ArticleDOI
Expression of membrane and nuclear melatonin receptors in mouse peripheral organs
TL;DR: The results suggest that melatonin, acting through its different subtypes receptors, plays a role in the neuroendocrine regulation of peripheral tissues function.
Journal ArticleDOI
Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential role of phytomelatonin
TL;DR: Melatonin receptor-mediated suppression of tumor growth, LA uptake and metabolism, and stimulation of tumor melatonin uptake and retention in response to the dietary intake of phytomelatonin from edible plants or melatonin from nutritional supplements, could play an important role in cancer growth prevention.
Journal ArticleDOI
The expression of MT1 and MT2 melatonin receptor mRNA in several rat tissues.
TL;DR: In this article, the expression of MT(1) and MT(2) melatonin receptor mRNA was determined using a real-time quantitative RT-PCR method, and the authors concluded that at least some effects of melatonin are mediated through membrane receptors in the hypothalamus, the retina and small intestine.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.
TL;DR: The analysis described shows K I does not equal I 50 when competitive inhibition kinetics apply; however, K I is equal to I 50 under conditions of either noncompetitive or uncompetitive kinetics.
Journal ArticleDOI
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
TL;DR: The cloning and characterization of a high affinity receptor for melatonin from the sheep and human is reported, likely mediates the reproductive and circadian actions of melatonin in mammals.
Journal ArticleDOI
Significance of melatonin in antioxidative defense system: reactions and products.
Dun Xian Tan,Lucien C. Manchester,Russel J. Reiter,Wenbo Qi,Malgorzata Karbownik,Juan R. Calvo +5 more
TL;DR: Melatonin in plants not only provides an alternative exogenous source of melatonin for herbivores but also suggests that melatonin may be an important antioxidant in plants which protects them from a hostile environment that includes extreme heat, cold and pollution, all of which generate free radicals.
Journal ArticleDOI
Pharmacology and function of melatonin receptors.
TL;DR: Recent advances in the pharmacological characterization of melatonin receptors in the central nervous system will further stimulate the search for potent and selective melatonin receptor agonists and antagonists, and should aid in the understanding of the mechanism of action ofmelatonin in mammalian brain.
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