Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.
Claire L. Holness,David Simmons +1 more
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CDNA clones encoding CD68 are isolated from a U937 cDNA library by transient expression in COS cells and panning with the anti-CD68 monoclonal antibodies Y2/131, Y1/82A, EBM11, and Ki-M6.Citations
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Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
Andrew C. Li,Kathleen K. Brown,Mercedes Silvestre,Timothy M. Willson,Wulf Palinski,Christopher K. Glass +5 more
TL;DR: It is reported that the PPARγ-specific agonists rosiglitazone and GW7845 strongly inhibited the development of atherosclerosis in LDL receptor‐deficient male mice, despite increased expression of the CD36 scavenger receptor in the arterial wall.
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Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.
M. K. Chang,Liza-Jane Raggatt,Kylie A. Alexander,Julia S. Kuliwaba,Nicola L. Fazzalari,Kate Schroder,Erin Maylin,Vera M. Ripoll,Vera M. Ripoll,David A. Hume,David A. Hume,Allison R. Pettit +11 more
TL;DR: It is demonstrated that OsteoMacs are an integral component of bone tissues and play a novel role in bone homeostasis through regulating osteoblast function and implicate OsteiMacs, in addition to osteoclasts and osteoblasts, as principal participants in bone dynamics.
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M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide.
TL;DR: These results evidence for the first time a clear protective effect of M2 on the contrary to M1 macrophages on etoposide-induced cancer cell apoptosis.
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The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
TL;DR: It was found that infiltration of CD163+ and CD68+ macrophages into tumor stroma, but not into tumor nest, were of clinical relevance and an independent prognostic factor for reduced breast cancer specific survival.
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Binding of Ovarian Cancer Antigen CA125/MUC16 to Mesothelin Mediates Cell Adhesion
Armin Rump,Yoshihiro Morikawa,Minoru Tanaka,Sawako Minami,Naohiko Umesaki,Masaki Takeuchi,Atsushi Miyajima,Atsushi Miyajima +7 more
TL;DR: The data indicate that mesothelin is a novel CA125-binding protein and that CA125 might contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to Mesothelin.
References
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DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
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A comprehensive set of sequence analysis programs for the VAX
TL;DR: A group of programs that will interact with each other has been developed for the Digital Equipment Corporation VAX computer using the VMS operating system.
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Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
TL;DR: Rolling of leukocytes on vascular endothelial cells, an early event in inflammation, can be reproduced in vitro on artificial lipid bilayers containing purified CD62, a selectin also named PADGEM and GMP-140 that is inducible on endothelial Cells.
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Rapid similarity searches of nucleic acid and protein data banks.
W. J. Wilbur,David J. Lipman +1 more
TL;DR: An algorithm for the global comparison of sequences based on matching k-tuples of sequence elements for a fixed k results in substantial reduction in the time required to search a data bank when compared with prior techniques of similarity analysis, with minimal loss in sensitivity.
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Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system
Alejandro Aruffo,Brian Seed +1 more
TL;DR: A cDNA clone encoding CD28 is isolated by a simple and highly efficient cloning strategy based on transient expression in COS cells based on the use of an efficient method to prepare large plasmid cDNA libraries.