Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.
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TLDR
The time course of mRNA accumulation was different for each of these mRNAs, indicating they do not respond synchronously during differentiation, and a recombinant bacterial library containing cDNA prepared from mRNA of adipose 3T3 cells is constructed.About:
This article is published in Journal of Biological Chemistry.The article was published on 1983-08-25 and is currently open access. It has received 450 citations till now. The article focuses on the topics: Complementary DNA & Messenger RNA.read more
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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
TL;DR: A role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance is suggested as well as the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA.
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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
TL;DR: A novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation is described.
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AdipoQ is a novel adipose-specific gene dysregulated in obesity.
TL;DR: The tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue.
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Understanding Adipocyte Differentiation
TL;DR: Characterization of regulatory regions of adipose-specific genes has led to the identification of the transcription factors peroxisome proliferator-activated receptor-gamma and CCAAT/enhancer binding protein (C/EBP), which play a key role in the complex transcriptional cascade during adipocyte differentiation.
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Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.
TL;DR: The central role of lipid chaperones — the fatty acid-binding proteins (FABPs) — in lipid-mediated biological processes and systemic metabolic homeostasis through the regulation of diverse lipid signals is discussed, and their therapeutic significance is highlighted.
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