Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements.
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TLDR
In this paper, a review focused on target genes as well as various cellular signaling pathways including Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF, and JAKs/STAT3, which are associated with CRC progression and metastasis.Abstract:
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide enhanced screening strategies, the prevalence of CRC is still on the rise. Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, analyzing signaling pathways involved in CRC metastasis is necessary to elucidate the underlying mechanism of CRC progression and pharmacotherapy. This review focused on target genes as well as various cellular signaling pathways including Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF, and JAKs/STAT3, which are associated with CRC progression and metastasis. Additionally, alternations in methylation patterns in relation with signaling pathways involved in regulating various cellular mechanisms such as cell cycle, transcription, apoptosis, and angiogenesis as well as invasion and metastasis were also reviewed. To date, understanding the genomic and epigenomic instability has identified candidate biomarkers that are validated for routine clinical use in CRC management. Nevertheless, better understanding of the onset and progression of CRC can aid in the development of early detection molecular markers and risk stratification methods to improve the clinical care of CRC patients.read more
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Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies
Md. Sanower Hossain,Hidayah Karuniawati,Ammar Abdulrahman Jairoun,Zannat Urbi,Der Jiun Ooi,Akbar John,Ya Chee Lim,K. M. Kaderi Kibria,A. K. M. Mohiuddin,Long Chiau Ming,Khang Wen Goh,Muhammad Abdul Hadi +11 more
TL;DR: This comprehensive review has comprehensively discussed the current global epidemiology, drug resistance, challenges, risk factors, and preventive and treatment strategies of colorectal cancer (CRC).
Journal ArticleDOI
Clinical management of metastatic colorectal cancer in the era of precision medicine
Fortunato Ciardiello,Davide Ciardiello,Giulia Martini,Stefania Napolitano,Josep Tabernero,Andrés Cervantes +5 more
TL;DR: This review summarizes the improvements in the clinical management of patients with mCRC in the emerging era of precision medicine.
Journal ArticleDOI
The Role of p53 Signaling in Colorectal Cancer.
TL;DR: In colorectal cancer (CRC), the TP53 gene is mutated in 43% of tumors, and the remaining tumors often have compromised p53 functioning because of alterations in the genes encoding proteins involved in p53 regulation, such as ATM (13%) or DNA-PKcs (11%). TP53 mutations in CRC are usually missense mutations that impair wild-type p53 function (loss-of-function) and that even might provide neo-morphic (gain-offunction) activities such as promoting cancer cell stemness, cell proliferation, invasion, and metast
Journal ArticleDOI
Plant-derived bioactive compounds in colon cancer treatment: An updated review.
Akanksha Esmeeta,Subhamay Adhikary,V. Dharshnaa,P. Swarnamughi,Z. Ummul Maqsummiya,S. Banerjee,Surajit Pathak,Asim K. Duttaroy +7 more
TL;DR: In this paper , the benefits and challenges of using bioactive compounds derived from plants for colon cancer were discussed and discussed using these compounds to target cancer stem cell self-renewal, its effects on cancer cell metabolism, safety parameters, easy modulation and their bioavailability.
Journal ArticleDOI
Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment.
TL;DR: Ru-complexes are reported to exert their anticancer activities in CRC cells by regulating different cell signaling pathways that are either directly or indirectly associated with cell growth, division, proliferation, and migration as mentioned in this paper.
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TL;DR: Integrative analyses suggest new markers for aggressive colorectal carcinoma and an important role for MYC-directed transcriptional activation and repression.