Journal ArticleDOI
Molecular photosensitisers for two-photon photodynamic therapy
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TLDR
The engineering of molecular two-photon photosensitisers for PDT should bring important benefits to the treatment, increase the treatment penetration depth with near-infrared light excitation, improve the spatial selectivity and reduce the photodamage to healthy tissues.About:
This article is published in Chemical Communications.The article was published on 2017-11-30. It has received 172 citations till now.read more
Citations
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I and i
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Journal ArticleDOI
Clinical development and potential of photothermal and photodynamic therapies for cancer
TL;DR: An overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challenges in this area and thus improve the efficiency and utility of such treatments are provided.
Journal ArticleDOI
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy.
TL;DR: In this paper, a review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, to provide intuitive, vivid, and specific insights to the readers.
Journal ArticleDOI
Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application.
TL;DR: Recent progress made in the development of PSs for overcoming nonnegligible challenges remain for its further clinical use, including finite tumor suppression, poor tumor targeting, and limited therapeutic depth are summarized.
Journal ArticleDOI
Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy
TL;DR: Recent developments involving photosensitisers containing Ru(II, Os(II), Pt, Pt, Ir(III), and Re(I) ions are summarized, indicating the bright future of this class of compounds in PDT.
References
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Journal ArticleDOI
I and i
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Journal ArticleDOI
Two-Photon Laser Scanning Fluorescence Microscopy
TL;DR: The fluorescence emission increased quadratically with the excitation intensity so that fluorescence and photo-bleaching were confined to the vicinity of the focal plane as expected for cooperative two-photon excitation.
Journal ArticleDOI
Deep tissue two-photon microscopy
Fritjof Helmchen,Winfried Denk +1 more
TL;DR: Fundamental concepts of nonlinear microscopy are reviewed and conditions relevant for achieving large imaging depths in intact tissue are discussed.
Journal ArticleDOI
Photodynamic therapy of cancer: An update†‡
Patrizia Agostinis,Kristian Berg,Keith A. Cengel,Thomas H. Foster,Albert W. Girotti,Sandra O. Gollnick,Stephen M. Hahn,Michael R. Hamblin,Michael R. Hamblin,Asta Juzeniene,David Kessel,Mladen Korbelik,Johan Emelian Moan,Johan Emelian Moan,Pawel Mroz,Dominika Nowis,Jacques Piette,Brian C. Wilson,Jakub Golab,Jakub Golab +19 more
TL;DR: The photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells as discussed by the authors, which can prolong survival in patients with inoperable cancers and significantly improve quality of life.
Journal ArticleDOI
Nonlinear magic: multiphoton microscopy in the biosciences
TL;DR: Multiphoton microscopy has found a niche in the world of biological imaging as the best noninvasive means of fluorescence microscopy in tissue explants and living animals and its use is now increasing exponentially.
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