Monomeric inhibitors of influenza neuraminidase enhance the hemagglutination inhibition activities of polyacrylamides presenting multiple C-sialoside groups.
TLDR
This study provides an example of synergy between two ligands directed toward the active sites of two different proteins, and reinforces the conclusion that steric stabilization is important for the activity of polyvalent inhibitors.About:
This article is published in Chemistry & Biology.The article was published on 1996-02-01 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Neuraminidase & Hemagglutination assay.read more
Citations
More filters
Journal ArticleDOI
Polymer Therapeutics: Concepts and Applications
Rainer Haag,Felix Kratz +1 more
TL;DR: An overview of polymer therapeutics is presented with a focus on concepts and examples that characterize the salient features of the drug-delivery systems.
Journal ArticleDOI
Multivalency as a chemical organization and action principle.
Carlo Fasting,Christoph A. Schalley,Marcus Weber,Oliver Seitz,Stefan Hecht,Beate Koksch,Jens Dernedde,Christina Graf,Ernst-Walter Knapp,Rainer Haag +9 more
TL;DR: In a systematic review of scaffold architectures, the underlying effects and control options will be demonstrated, and suggestions will be given for designing effective multivalent binding systems, as well as for polyvalent therapeutics.
Journal ArticleDOI
Polyvalente Wechselwirkungen in biologischen Systemen: Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren
TL;DR: In this article, polyvalent Wechselwirkungen viel starker sein als entsprechende monovalente Wechwirthungen, and sie konnen die Basis fur das Verstandnis fordernder und hemmender biologischer Wechungungen liefern, die sich grundsatzlich von denen in monovalenten Systemen unterscheiden.
Journal ArticleDOI
Thermodynamic studies of lectin-carbohydrate interactions by isothermal titration calorimetry.
Tarun K. Dam,C. Fred Brewer +1 more
Journal ArticleDOI
Strength in numbers: non-natural polyvalent carbohydrate derivatives
TL;DR: New structural templates for the generation of multivalent carbohydrate displays have recently been developed, and tailored multivalent saccharide derivatives can now be used to study and modulate a wide variety of biological recognition events.
References
More filters
Journal ArticleDOI
Rational design of potent sialidase-based inhibitors of influenza virus replication.
Mark von Itzstein,Wen-Yang Wu,Gaik B. Kok,Michael S. Pegg,Jeffrey Clifford Dyason,Betty Jin,Tho Van Phan,Mark L. Smythe,Hume Forrest White,Hume Forrest White,Stuart W. Oliver,Peter M. Colman,Joseph N. Varghese,D. Michael Ryan,Jacqueline M. Woods,Richard C. Bethell,Vanessa J. Hotham,Janet M. Cameron,Charles R. Penn +18 more
TL;DR: Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed and provide an example of the power of rational, computer-assisted drug design, indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.
Journal ArticleDOI
The Structure and Function of the Hemagglutinin Membrane Glycoprotein of Influenza Virus
Don C. Wiley,John J. Skehel +1 more
Journal ArticleDOI
Influenza virus M2 protein has ion channel activity.
TL;DR: Analysis of the currents of altered M2 proteins suggests that the channel pore is formed by the transmembrane domain of the M2 protein, which is proposed to have a pivotal role in the biology of influenza virus infection.
Journal ArticleDOI
Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-alpha-D-N-acetylneuraminate) substrate.
TL;DR: Neuraminidase activity was considerably reduced in cultured fibroblasts of patients with mucolipidosis types I, II, and III and in cultured Fibroblast and leucocyte neuraminidases showed maximum activity between pH 4.2 and 4.4.
Journal Article
Future influenza vaccines and the use of genetic recombinants.
TL;DR: It is proposed that a prefabricated "library" of recombinants might anticipate the mutations which may arise in the future and also that live virus vaccines of greater stability may be produced by recombination of new and old viruses.