MR-proADM as prognostic factor of outcome in COVID-19 patients.
Emanuela Sozio,Carlo Tascini,Martina Fabris,Federica D'Aurizio,Chiara De Carlo,Elena Graziano,Flavio Bassi,Francesco Sbrana,Andrea Ripoli,Alberto Pagotto,Alessandro Giacinta,Valentina Gerussi,Daniela Visentini,Paola De Stefanis,Maria Merelli,Kordo Saeed,Francesco Curcio +16 more
TLDR
In this paper, a pragmatic retrospective analysis was performed on a complete data set from 111 patients admitted to Udine University Hospital, in northern Italy, from 25th March to 15th May 2020, affected by SARS-CoV-2 pneumonia.Abstract:
Mid Regional pro-ADM (MR-proADM) is a promising novel biomarker in the evaluation of deteriorating patients and an emergent prognosis factor in patients with sepsis, septic shock and organ failure. It can be induced by bacteria, fungi or viruses. We hypothesized that the assessment of MR-proADM, with or without other inflammatory cytokines, as part of a clinical assessment of COVID-19 patients at hospital admission, may assist in identifying those likely to develop severe disease. A pragmatic retrospective analysis was performed on a complete data set from 111 patients admitted to Udine University Hospital, in northern Italy, from 25th March to 15th May 2020, affected by SARS-CoV-2 pneumonia. Clinical scoring systems (SOFA score, WHO disease severity class, SIMEU clinical phenotype), cytokines (IL-6, IL-1b, IL-8, TNF-α), and MR-proADM were measured. Demographic, clinical and outcome data were collected for analysis. At multivariate analysis, high MR-proADM levels were significantly associated with negative outcome (death or orotracheal intubation, IOT), with an odds ratio of 4.284 [1.893-11.413], together with increased neutrophil count (OR = 1.029 [1.011-1.049]) and WHO disease severity class (OR = 7.632 [5.871-19.496]). AUROC analysis showed a good discriminative performance of MR-proADM (AUROC: 0.849 [95% Cl 0.771-0.730]; p < 0.0001). The optimal value of MR-proADM to discriminate combined event of death or IOT is 0.895 nmol/l, with a sensitivity of 0.857 [95% Cl 0.728-0.987] and a specificity of 0.687 [95% Cl 0.587-0.787]. This study shows an association between MR-proADM levels and the severity of COVID-19. The assessment of MR-proADM combined with clinical scoring systems could be of great value in triaging, evaluating possible escalation of therapies, and admission avoidance or inclusion into trials. Larger prospective and controlled studies are needed to confirm these findings.read more
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Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis
Rundong Qin,Li He,Zhaowei Yang,Nan Jia,Ruchong Chen,Jiaxing Xie,Wanyi Fu,Haoxuan Chen,Xinliu Lin,Renbin Huang,Tianyue Luo,Yukai Liu,Simin Yao,Mei Jiang,Jing Li +14 more
TL;DR: In this paper , the authors conducted an electronic search of PubMed, Scopus, Ovid, Willey, Web of Science, Cochrane library, and CNKI for studies reporting immunological and/or immune related parameters, including hematological, inflammatory, coagulation, and biochemical variables, tested on hospital admission of COVID-19 patients with different severities and outcomes.
Journal ArticleDOI
Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients.
Luis García de Guadiana-Romualdo,Monica Martinez,María Dolores Rodríguez Mulero,Patricia Esteban-Torrella,Marta Hernández Olivo,María José Alcaraz García,Valerio Campos-Rodríguez,Natalia Sancho-Rodríguez,María Galindo Martínez,Antonia Alcaraz,María Salomé Ros Braquehais,Carlos Báguena Perez-Crespo,Verónica Ramos Arenas,Cristina Tomás Jiménez,Luciano Consuegra-Sánchez,Andrés Conesa-Hernandez,Pascual Piñera-Salmerón,Enrique Bernal-Morell +17 more
TL;DR: In this article, the role of MR-proADM in the mid-term mortality in COVID-19 patients was evaluated and it was shown that MR-ProADM levels (inverse transformed), after adjusting by a propensity score including eleven potential confounders, were an independent predictor of 90-day mortality.
Journal ArticleDOI
Endothelium-associated biomarkers mid-regional proadrenomedullin and C-terminal proendothelin-1 have good ability to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia: A prospective cohort study.
Jos A H van Oers,Yvette Kluiters,Judith A P Bons,Mariska de Jongh,Sjaak Pouwels,Dharmanand Ramnarain,Dylan W. de Lange,Harm-Jan de Grooth,Armand R. J. Girbes +8 more
TL;DR: In this paper, the ability of mid-regional proadrenomedullin (MR-proADM) and C-terminal proendothelin-1 (CT-proET-1) to predict 28-day mortality in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia was assessed.
Journal ArticleDOI
Mid-regional pro-adrenomedullin as a supplementary tool to clinical parameters in cases of suspicion of infection in the emergency department.
Kordo Saeed,Jacopo M. Legramante,Silvia Angeletti,Francesco Curcio,Iria Miguens,Stephen Poole,Carlo Tascini,Emanuela Sozio,Juan González del Castillo +8 more
TL;DR: In this paper, the authors provide evidence related to MR-proADM as a triaging tool in avoiding unnecessary admissions to hospital and/or inadequate discharge, and identifying patients most at risk of deterioration.
Journal ArticleDOI
Prognostic value of copeptin and mid‐regional proadrenomedullin in COVID‐19‐hospitalized patients
Rita Indirli,Alessandra Bandera,Luca Valenti,Ferruccio Ceriotti,Adriana di Modugno,Mauro Tettamanti,Roberta Gualtierotti,Flora Peyvandi,Nicola Montano,Francesco Blasi,Giorgio Costantino,Veronica Resi,Emanuela Orsi,M. Ambrosio,Giovanni Mantovani,Emanuele Ferrante +15 more
TL;DR: This study aimed to assess whether copeptin and MR‐proADM could predict coronavirus disease 2019 (COVID‐19) in‐hospital outcomes, that is multi‐system complications, length of stay and mortality.
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