Journal ArticleDOI
Mucins, Mucus, and Sputum*
Judith A. Voynow,Bruce K. Rubin +1 more
TLDR
Mucin glycoprotein overproduction and hypersecretion are common features of chronic inflammatory airway disease, and this has been the underlying rationale to investigate the mechanisms of mucin gene regulation and mucin secretion.About:
This article is published in Chest.The article was published on 2009-02-01. It has received 465 citations till now. The article focuses on the topics: Mucin & Mucus.read more
Citations
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Journal ArticleDOI
Respiratory epithelial cells orchestrate pulmonary innate immunity
TL;DR: The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.
Journal ArticleDOI
The Airway Epithelium: Soldier in the Fight against Respiratory Viruses
TL;DR: The airway epithelium acts as a frontline defense against respiratory viruses, not only as a physical barrier and through the mucociliary apparatus but also through its immunological functions, which initiates multiple innate and adaptive immune mechanisms which are crucial for efficient antiviral responses.
Journal ArticleDOI
Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications
Soichiro Kanoh,Bruce K. Rubin +1 more
TL;DR: Macrolides have diverse biological activities and an ability to modulate inflammation and immunity in eukaryotes without affecting homeostatic immunity, which led to their long-term use in treating neutrophil-dominated inflammation in diffuse panbronchiolitis, bronchiectasis, rhinosinusitis, and cystic fibrosis.
Journal ArticleDOI
Innate Immunity in the Respiratory Epithelium
Dane Parker,Alice Prince +1 more
TL;DR: This review focuses on the innate immune capabilities of the airway epithelium and its role in protecting the lung from infection as well as the outcomes when its function is compromised.
Journal ArticleDOI
The sentinel role of the airway epithelium in asthma pathogenesis
TL;DR: In this paper, it was shown that asthma is primarily an epithelial disorder and that its origin as well as its clinical manifestations have more to do with altered epithelial physical and functional barrier properties than being purely linked to allergic pathways.
References
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Journal ArticleDOI
Interleukin-13: Central Mediator of Allergic Asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this paper, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal Article
Interleukin-13: Central mediator of allergic asthma
Marsha Wills-Karp,Jackie Luyimbazi,Xueying Xu,Brian Schofield,Tamlyn Neben,Christopher L. Karp,Debra D. Donaldson +6 more
TL;DR: In this article, the type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma.
Journal ArticleDOI
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
Maria van der Sluis,Barbara A. E. de Koning,Adrianus C. J. M. de Bruijn,Anna Velcich,Jules P.P. Meijerink,Johannes B. van Goudoever,Hans A. Büller,Jan Dekker,Isabelle Van Seuningen,Ingrid B. Renes,Alexandra W. C. Einerhand +10 more
TL;DR: This study shows that Muc2 deficiency leads to inflammation of the colon and contributes to the onset and perpetuation of experimental colitis.
Journal ArticleDOI
Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease
Mary C. Rose,Judith A. Voynow +1 more
TL;DR: Understanding the pathways and processes that lead to mucus overproduction in specific airway diseases will allow circumvention or amelioration of these processes, and deficiencies in understanding the functional roles of mucins at the molecular level are identified as areas for further investigations that will impact on airway health and disease.
Journal ArticleDOI
Colorectal cancer in mice genetically deficient in the mucin Muc2.
Anna Velcich,Wancai Yang,Joerg Heyer,Alessandra Fragale,Courtney Nicholas,Stephanie Viani,Raju Kucherlapati,Martin Lipkin,Kan Yang,Leonard H. Augenlicht +9 more
TL;DR: Muc2 is involved in the suppression of colorectal cancer and frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors.
Related Papers (5)
Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease
Mary C. Rose,Judith A. Voynow +1 more