Respiratory epithelial cells orchestrate pulmonary innate immunity
TLDR
The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.Abstract:
The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.read more
Citations
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Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.
Yanfang Liu,Yan Gu,Yanmei Han,Qian Zhang,Zhengping Jiang,Xiang Zhang,Bo Huang,Xiaoqing Xu,Jianming Zheng,Xuetao Cao,Xuetao Cao +10 more
TL;DR: It is demonstrated that lung epithelial cells are critical for initiating neutrophil recruitment and lung metastatic niche formation by sensing tumor exosomal RNAs via Toll-like receptor 3 (TLR3), and TLR3-deficient mice show reduced lung metastasis in the spontaneous metastatic models.
Journal ArticleDOI
Innate immune responses to trauma
TL;DR: This Review aims to provide basic concepts about the posttraumatic response and is focused on the interactive events of innate immunity at frequent sites of injury: the endothelium at large, and sites within the lungs, inside and outside the brain and at the gut barrier.
Journal ArticleDOI
Allergic inflammatory memory in human respiratory epithelial progenitor cells.
Jose Ordovas-Montanes,Daniel F. Dwyer,Daniel F. Dwyer,Sarah K. Nyquist,Kathleen M. Buchheit,Kathleen M. Buchheit,Marko Vukovic,Chaarushena Deb,Marc H. Wadsworth,Travis K. Hughes,Samuel W. Kazer,Eri Yoshimoto,Eri Yoshimoto,Katherine N. Cahill,Katherine N. Cahill,Neil Bhattacharyya,Neil Bhattacharyya,Howard R. Katz,Howard R. Katz,Bonnie Berger,Tanya M. Laidlaw,Tanya M. Laidlaw,Joshua A. Boyce,Joshua A. Boyce,Nora A. Barrett,Nora A. Barrett,Alex K. Shalek +26 more
TL;DR: It is found that reduced epithelial diversity stemming from functional shifts in basal cells is a key characteristic of type 2 immune-mediated barrier tissue dysfunction and may contribute to the persistence of human disease by serving as repositories for allergic memories.
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