Journal ArticleDOI
Nanodiamonds and their potential applications in breast cancer therapy: a narrative review.
TLDR
In this article, the authors present an update on preclinical findings of nanodiamond-based drug delivery systems for breast cancer therapy to date, challenges with the use of Nanodiamonds along with considerations for future research.Abstract:
Breast cancer remains the most commonly diagnosed cancer and the leading cause of cancer-related death among women worldwide. With the projected increase in breast cancer cases in recent years, optimising treatment becomes increasingly important. Current treatment modalities in breast cancer present major limitations, including chemoresistance, dose-limiting adverse effects and lack of selectivity in aggressive subtypes of breast cancers such as triple-negative breast cancer. Nanodiamonds have demonstrated promising outcomes in preclinical models from their unique surface characteristics allowing optimised delivery of various therapeutic agents, overcoming some of the significant hurdles in conventional treatment modalities. This review will present an update on preclinical findings of nanodiamond-based drug delivery systems for breast cancer therapy to date, challenges with the use of nanodiamonds along with considerations for future research.read more
Citations
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Effects of Metallic and Carbon-Based Nanomaterials on Human Pancreatic Cancer Cell Lines AsPC-1 and BxPC-3.
Barbara Wójcik,Ewa Sawosz,Jarosław Szczepaniak,Barbara Strojny,Malwina Sosnowska,Karolina Daniluk,Marlena Zielińska-Górska,Jaśmina Bałaban,André Chwalibog,Mateusz Wierzbicki +9 more
TL;DR: In this article, the authors evaluated the toxicity of nanomaterials against human pancreatic adenocarcinoma cell lines and found that the highest cytotoxicity was obtained after the diamond treatment.
References
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Journal ArticleDOI
A critical review of nanodiamond based nanocomposites: Synthesis, properties and applications
TL;DR: In this article, the properties of nanodiamonds and their application in polymer composites, electronics, energy, environmental areas and biological areas were analyzed, and their properties were shown to be useful in biological applications.
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Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells
TL;DR: dND-PG is a promising drug carrier for realization of highly selective drug delivery in tumor cells through specific uptake mechanisms, with minimum uptake in and influence on macrophages.
Journal ArticleDOI
Deaggregation of Nanodiamond Powders Using Salt- and Sugar-Assisted Milling
TL;DR: Using the dry media assisted milling with subsequent pH adjustment, it is possible to produce stable aqueous nanodiamond colloidal solutions with particles <10 nm in diameter, which corresponds to 1-2 primary nanod diamond particles.
Journal ArticleDOI
Pulmonary toxicity and translocation of nanodiamonds in mice
Yuan Yuan,Xiang Wang,Guang Jia,Jia-Hui Liu,Tiancheng Wang,Yiqun Gu,Sheng-Tao Yang,Sen Zhen,Haifang Wang,Haifang Wang,Yuanfang Liu,Yuanfang Liu +11 more
TL;DR: It is affirm the critical role of alveolar macrophages in the main excretion pathway of NDs from the lungs, i.e. they engulf the NDs, migrate upward to the trachea by escalator/mucociliary system and finally enter the pharynx.
Journal ArticleDOI
Imaging of triple-negative breast cancer
Basak E. Dogan,L. W. Turnbull +1 more
TL;DR: MRI consistently demonstrates the presence of all TNBC with a higher level of accuracy compared with other tumour sub-types, and provides a reliable baseline for neoadjuvant chemotherapy (NAC) follow-up, and preliminary studies suggest that MRI may predict complete NAC response in TNBC more sensitively than other methods.