Journal ArticleDOI
Nanodiamonds and their potential applications in breast cancer therapy: a narrative review.
TLDR
In this article, the authors present an update on preclinical findings of nanodiamond-based drug delivery systems for breast cancer therapy to date, challenges with the use of Nanodiamonds along with considerations for future research.Abstract:
Breast cancer remains the most commonly diagnosed cancer and the leading cause of cancer-related death among women worldwide. With the projected increase in breast cancer cases in recent years, optimising treatment becomes increasingly important. Current treatment modalities in breast cancer present major limitations, including chemoresistance, dose-limiting adverse effects and lack of selectivity in aggressive subtypes of breast cancers such as triple-negative breast cancer. Nanodiamonds have demonstrated promising outcomes in preclinical models from their unique surface characteristics allowing optimised delivery of various therapeutic agents, overcoming some of the significant hurdles in conventional treatment modalities. This review will present an update on preclinical findings of nanodiamond-based drug delivery systems for breast cancer therapy to date, challenges with the use of nanodiamonds along with considerations for future research.read more
Citations
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Effects of Metallic and Carbon-Based Nanomaterials on Human Pancreatic Cancer Cell Lines AsPC-1 and BxPC-3.
Barbara Wójcik,Ewa Sawosz,Jarosław Szczepaniak,Barbara Strojny,Malwina Sosnowska,Karolina Daniluk,Marlena Zielińska-Górska,Jaśmina Bałaban,André Chwalibog,Mateusz Wierzbicki +9 more
TL;DR: In this article, the authors evaluated the toxicity of nanomaterials against human pancreatic adenocarcinoma cell lines and found that the highest cytotoxicity was obtained after the diamond treatment.
References
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Journal ArticleDOI
Fluorescent nanodiamonds: past, present, and future
Masfer Alkahtani,Masfer Alkahtani,Fahad Alghannam,Fahad Alghannam,Linkun Jiang,Abdulrahman Almethen,Abdulrahman Almethen,Arfaan A. Rampersaud,Robert Brick,Carmen L. Gomes,Marlan O. Scully,Marlan O. Scully,Philip R. Hemmer +12 more
TL;DR: Fluorescent nanodiamonds (FNDs) are promising fluorescent markers for biomedical applications as mentioned in this paper, which have the advantage of lower toxicity, exceptional chemical stability, and better photostability.
Journal ArticleDOI
Controlling angiogenesis in breast cancer: a systematic review of anti-angiogenic trials.
John R. Mackey,Robert S. Kerbel,Karen A. Gelmon,Deanna McLeod,Stephen Chia,Daniel Rayson,Sunil Verma,Loretta L. Collins,Alexander H.G. Paterson,André Robidoux,Kathleen I. Pritchard +10 more
TL;DR: Most trials of anti-angiogenic agents in BC have reported improved response rate and progression-free survival but no increase in overall survival compared to chemotherapy alone.
Journal ArticleDOI
Nanodiamond-mediated drug delivery and imaging: challenges and opportunities.
V. Vaijayanthimala,Dong-Keun Lee,Sue V Kim,Albert Yen,Nathaniel Tsai,Dean Ho,Huan-Cheng Chang,Olga Shenderova +7 more
TL;DR: A unique set of properties of ND particles attractive for drug delivery and imaging applications are described, including exceptional biocompatibility, large carrier capacity and versatile surface chemistry properties, which enhance drug binding and provide sustainable drug release.
Journal ArticleDOI
Advanced diamond-reinforced metal matrix composites via cold spray: properties and deposition mechanism
Shuo Yin,Yingchun Xie,Jan Cizek,Emmanuel J. Ekoi,Tanvir Hussain,Denis P. Dowling,Rocco Lupoi +6 more
TL;DR: In this article, a diamond-reinforced metal matrix composites (DMMC) was applied to aluminum alloy substrate via cold spray of three feedstock powders: copper-clad diamond and pure copper, and their mixtures.
Journal ArticleDOI
Mechanism-independent optimization of combinatorial nanodiamond and unmodified drug delivery using a phenotypically driven platform technology.
Hann Wang,Dong-Keun Lee,Kai-Yu Chen,Jing-Yao Chen,Kangyi Zhang,Aleidy Silva,Chih-Ming Ho,Dean Ho +7 more
TL;DR: A powerful phenotypically driven platform, termed feedback system control (FSC), is applied that systematically and rapidly converges upon a combination consisting of three nanodiamond-modified drugs and one unmodified drug that is simultaneously optimized for efficacy against multiple breast cancer cell lines and safety against multiple control cell lines.