Journal ArticleDOI
Nanodiamonds and their potential applications in breast cancer therapy: a narrative review.
TLDR
In this article, the authors present an update on preclinical findings of nanodiamond-based drug delivery systems for breast cancer therapy to date, challenges with the use of Nanodiamonds along with considerations for future research.Abstract:
Breast cancer remains the most commonly diagnosed cancer and the leading cause of cancer-related death among women worldwide. With the projected increase in breast cancer cases in recent years, optimising treatment becomes increasingly important. Current treatment modalities in breast cancer present major limitations, including chemoresistance, dose-limiting adverse effects and lack of selectivity in aggressive subtypes of breast cancers such as triple-negative breast cancer. Nanodiamonds have demonstrated promising outcomes in preclinical models from their unique surface characteristics allowing optimised delivery of various therapeutic agents, overcoming some of the significant hurdles in conventional treatment modalities. This review will present an update on preclinical findings of nanodiamond-based drug delivery systems for breast cancer therapy to date, challenges with the use of nanodiamonds along with considerations for future research.read more
Citations
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Effects of Metallic and Carbon-Based Nanomaterials on Human Pancreatic Cancer Cell Lines AsPC-1 and BxPC-3.
Barbara Wójcik,Ewa Sawosz,Jarosław Szczepaniak,Barbara Strojny,Malwina Sosnowska,Karolina Daniluk,Marlena Zielińska-Górska,Jaśmina Bałaban,André Chwalibog,Mateusz Wierzbicki +9 more
TL;DR: In this article, the authors evaluated the toxicity of nanomaterials against human pancreatic adenocarcinoma cell lines and found that the highest cytotoxicity was obtained after the diamond treatment.
References
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Journal ArticleDOI
Stealth Coating of Nanoparticles in Drug-Delivery Systems.
See Yee Fam,Chin Fei Chee,Chean Yeah Yong,Kok Lian Ho,Abdul Razak Mariatulqabtiah,Wen Siang Tan +5 more
TL;DR: This review focuses on the basic concept underlying the stealth behavior of NPs by polymer coating, whereby the fundamental surface coating characteristics such as molecular weight, surface chain density as well as conformations of polymer chains are of utmost importance for efficient protection of NPS.
Journal ArticleDOI
Theranostic applications of carbon nanomaterials in cancer: Focus on imaging and cargo delivery.
TL;DR: The current state-of-the-art applications of carbon nanomaterials in cancer imaging and drug delivery/therapy are summarized andMultifunctional carbon nanoplatforms have the potential to serve as optimal candidates for image-guided delivery vectors for cancer.
Journal ArticleDOI
Nanodiamonds: The intersection of nanotechnology, drug development, and personalized medicine.
TL;DR: This review will examine various nanomaterials and the use of PPM-DD to optimize the efficacy and safety of current and future cancer treatment and how this platform can accelerate combinatorial nanomedicine and the broader pharmaceutical industry toward unprecedented clinical impact.
Journal ArticleDOI
Nanodiamond-Polymer Composites
Vadym Mochalin,Yury Gogotsi +1 more
TL;DR: • Advantages of nanodiamond in polymer composites: superior mechanical properties, nanometer size, and fully available surface as discussed by the authors, which can be used to construct polymeric composites.
Journal ArticleDOI
Biodistribution and fate of nanodiamonds in vivo
TL;DR: In this paper, the authors found that NDs with a diameter of around 50nm predominantly accumulated in liver after intravenous injection to mouse and Spleen and lung were also target organs for NDs.