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Nanomedicine: A new frontier in cancer therapeutics
Pui Yan Lee,Kenneth K Y Wong +1 more
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TLDR
The evolution history, the challenges and the role of nanoparticles in cancer drug delivery will briefly be discussed together with additional opportunities in cancer therapy.Abstract:
Nanotechnology is a cutting edge and rapidly evolving technology in medicine. The potential of nanomedicine in cancer therapy is infinitely promising due to the fact that novel developments are constantly being explored. This is particularly the case in the use of nanoparticles in both tumor diagnosis, as well as treatment. This article will attempt to describe some recent advances using nanoparticle drug delivery system in cancer therapy. The evolution history, the challenges and the role of nanoparticles in cancer drug delivery will briefly be discussed together with additional opportunities in cancer therapy. An overall understanding of these issues will help with further advancement of designing better drug delivery system that can be applied clinically.read more
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The History of Nanoscience and Nanotechnology: From Chemical–Physical Applications to Nanomedicine
TL;DR: This review illustrates the progress and main principles of nanoscience and nanotechnology and represents the pre-modern as well as modern timeline era of discoveries and milestones in these fields.
Journal ArticleDOI
Combining Magnetic Hyperthermia and Photodynamic Therapy for Tumor Ablation with Photoresponsive Magnetic Liposomes
Riccardo Di Corato,Gaëlle Béalle,Jelena Kolosnjaj-Tabi,Jelena Kolosnjaj-Tabi,Ana Espinosa,Olivier Clément,Amanda K. A. Silva,Christine Ménager,Claire Wilhelm +8 more
TL;DR: An optimized smart nanoplatform based on dually loaded hybrid liposomes to achieve enhanced tumor therapy resulted in complete cancer cell death in vitro while total solid-tumor ablation was achieved in an in vivo rodent model.
Journal ArticleDOI
Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo
Jing Liu,Pengyang Wang,Xiao Zhang,Liming Wang,Dongliang Wang,Zhanjun Gu,Jinglong Tang,Mengyu Guo,Mingjing Cao,Huige Zhou,Ying Liu,Chunying Chen +11 more
TL;DR: Results reveal that Cu3BiS3 NDs act as a simple but powerful "theranostic" nanoplatform for MSOT/CT imaging-guided tumor ablation with excellent metabolism and rapid clearance that will improve safety for clinical applications in the future.
Journal ArticleDOI
Dextran-based doxorubicin nanocarriers with improved tumor penetration
Sharon M. Sagnella,Hien T. T. Duong,Alexander Macmillan,Cyrille Boyer,Renee Whan,Joshua A. McCarroll,Thomas P. Davis,Thomas P. Davis,Maria Kavallaris +8 more
TL;DR: The ald-dex-dox nanocarriers represent a promising therapeutic delivery system for the treatment of solid tumors due to their unique enhanced penetration ability combined with their improved efficacy over the parent drug in 3D.
Journal ArticleDOI
Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: in vitro and in vivo studies.
TL;DR: OEG-SN38 exhibited potent antitumor activity against a panel of human tumor cell lines, as well as favorable antitumors activity and high safety in human xenograft models, and showed greatly improved drug loading, solubility and stability.
References
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Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal ArticleDOI
Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
TL;DR: The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Drug Delivery Systems: Entering the Mainstream
TL;DR: There is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
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