Journal ArticleDOI
Nanotoxicology: Nanoparticles versus the placenta
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TLDR
Pregnant mice treated with 70-nm silica nanoparticles or 35-nm titanium dioxide nanoparticles suffer damage to the placenta and fetus, whereas larger nanoparticles do not have an adverse impact.Abstract:
Pregnant mice treated 70-nm silica nanoparticles or 35-nm titanium dioxide nanoparticles suffer damage to the placenta and fetus, whereas larger nanoparticles do not have an adverse impact.read more
Citations
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Journal ArticleDOI
Inhaled Nanoparticles Accumulate at Sites of Vascular Disease
Mark R. Miller,Jennifer Raftis,Jeremy P. Langrish,Steven G. McLean,Pawitrabhorn Samutrtai,Shea P. Connell,Simon Wilson,Alex T. Vesey,Paul H. B. Fokkens,A. John F. Boere,Petra Krystek,Colin Campbell,Patrick W. F. Hadoke,Ken Donaldson,Flemming R. Cassee,David E. Newby,Rodger Duffin,Nicholas L. Mills +17 more
TL;DR: Translocation of inhaled nanoparticles into the systemic circulation and accumulation at sites of vascular inflammation provides a direct mechanism that can explain the link between environmental nanoparticles and cardiovascular disease and has major implications for risk management in the use of engineered nanomaterials.
Journal ArticleDOI
Advances in the application, toxicity and degradation of carbon nanomaterials in environment: A review.
Zan Peng,Xiaojuan Liu,Wei Zhang,Zhuotong Zeng,Zhifeng Liu,Chang Zhang,Yang Liu,Binbin Shao,Qinghua Liang,Wangwang Tang,Xingzhong Yuan +10 more
TL;DR: This work systematically describes the toxicity of carbon nanotubes, graphene, GRA and C60 to cells, animals, humans, and microorganisms and has prospects for the limitations of CNM degradation under non-experimental conditions and their potential application.
Journal ArticleDOI
Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity
Ramin Sakhtianchi,Rodney F. Minchin,Ki-Bum Lee,Alaaldin M. Alkilany,Vahid Serpooshan,Morteza Mahmoudi,Morteza Mahmoudi +6 more
TL;DR: An overview of how NPs are handled intracellularly and how they are excreted from cells following the uptake is presented and how exocytosis of nanomaterials impacts both the therapeutic delivery of nanoscale objects and their nanotoxicology is discussed.
Journal ArticleDOI
Assessing clinical prospects of silicon quantum dots: studies in mice and monkeys.
Jianwei Liu,Folarin Erogbogbo,Folarin Erogbogbo,Ken-Tye Yong,Ling Ye,Jing Liu,Rui Hu,Hongyan Chen,Yazhuo Hu,Yi Yang,Jinghui Yang,Indrajit Roy,Nicholas Karker,Mark T. Swihart,Paras N. Prasad,Paras N. Prasad +15 more
TL;DR: It is shown that neither mice nor monkeys show overt signs of toxicity reflected in their behavior, body mass, or blood chemistry, even at a dose of 200 mg/kg, and the formulation did not biodegrade as expected.
References
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Journal ArticleDOI
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice.
Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Kazuya Mimura,Yuki Morishita,Masatoshi Nozaki,Tokuyuki Yoshida,Toshinobu Ogura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Youko Monobe,Takayoshi Imazawa,Hisae Aoshima,Kiyoshi Shishido,Yuichi Kawai,Tadanori Mayumi,Shin-ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Itaru Yanagihara,Shigeru Saito,Yasuo Tsutsumi +23 more
TL;DR: In this paper, the authors showed that nanoparticles with diameters of 70 nm and 35 nm can cause pregnancy complications when injected intravenously into pregnant mice, and that these detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups.
Journal ArticleDOI
Biodistribution of 1.4‐ and 18‐nm Gold Particles in Rats
Manuela Semmler-Behnke,Wolfgang G. Kreyling,Jens Lipka,Stefanie Fertsch,Alexander Wenk,Shinji Takenaka,Günter Schmid,Wolfgang Brandau +7 more
Journal ArticleDOI
Barrier Capacity of Human Placenta for Nanosized Materials
Peter Wick,Antoine Malek,Pius Manser,Danielle Meili,Xenia Maeder-Althaus,Liliane Diener,Pierre-André Diener,Andreas H. Zisch,Harald F. Krug,Ursula von Mandach +9 more
TL;DR: The findings suggest that nanomaterials have the potential for transplacental transfer and underscore the need for further nanotoxicologic studies on this important organ system.
Journal ArticleDOI
Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems
Ken Takeda,Kenichiro Suzuki,Aki Ishihara,Miyoko Kubo-Irie,Rie Fujimoto,Masako Tabata,Shigeru Oshio,Yoshimasa Nihei,Tomomi Ihara,Masao Sugamata +9 more
TL;DR: It is shown that nano-sized titanium dioxide (TiO2), which is used widely as a photo-catalyst and in consumer products, administered subcutaneously to pregnant mice is transferred to the offspring and affects the genital and cranial nerve systems of the male offspring.
Journal ArticleDOI
Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo
TL;DR: In vivo and in vitro action of C60 on embryogenesis is a novel and seriously harmful activity, although weaker than the vehicle controls.
Related Papers (5)
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice.
Kohei Yamashita,Yasuo Yoshioka,Kazuma Higashisaka,Kazuya Mimura,Yuki Morishita,Masatoshi Nozaki,Tokuyuki Yoshida,Toshinobu Ogura,Hiromi Nabeshi,Kazuya Nagano,Yasuhiro Abe,Haruhiko Kamada,Youko Monobe,Takayoshi Imazawa,Hisae Aoshima,Kiyoshi Shishido,Yuichi Kawai,Tadanori Mayumi,Shin-ichi Tsunoda,Norio Itoh,Tomoaki Yoshikawa,Itaru Yanagihara,Shigeru Saito,Yasuo Tsutsumi +23 more