Journal ArticleDOI
Neurobiology and consequences of social isolation stress in animal model-A comprehensive review.
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TLDR
In several regions of the central nervous system (CNS), SIS alters the level of neurotransmitter such as dopamine, serotonin, gamma aminobutyric acid, glutamate, nitrergic system and adrenaline as well as leads to alteration in receptor sensitivity of N-methyl-D-aspartate (NMDA) and opioid system.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2018-09-01. It has received 204 citations till now. The article focuses on the topics: Neurochemical & Glutamate receptor.read more
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COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options.
Tomasz J. Guzik,Tomasz J. Guzik,Saidi A Mohiddin,Anthony Dimarco,Vimal Patel,K Savvatis,Federica M. Marelli-Berg,Meena S. Madhur,Maciej Tomaszewski,Pasquale Maffia,Pasquale Maffia,Fulvio D'Acquisto,Stuart A. Nicklin,Ali J. Marian,Ryszard Nosalski,Ryszard Nosalski,Eleanor Murray,Bartłomiej Guzik,Colin Berry,Rhian M. Touyz,Reinhold Kreutz,Dao Wen Wang,David Bhella,Orlando Sagliocco,Filippo Crea,E. Thomson,Iain B. McInnes +26 more
TL;DR: While ACE2 is essential for viral invasion, there is no evidence that ACE inhibitors or angiotensin receptor blockers (ARBs) worsen prognosis, Hence, patients should not discontinue their use.
Journal ArticleDOI
Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis
Andreina Baj,Elisabetta Moro,Michela Bistoletti,Viviana Teresa Orlandi,Francesca Crema,Cristina Giaroni +5 more
TL;DR: This review provides a description of the most up-to-date evidence on glutamate as a neurotransmitter/neuromodulator in this bidirectional communication axis and opens the possibility to target glutamatergic neurotransmission, either pharmacologically or by the use of probiotics producing neuroactive molecules, as a therapeutic approach for the treatment of gastrointestinal and related psychiatric disorders.
Journal ArticleDOI
The social life of Norway rats (Rattus norvegicus).
TL;DR: An overview of recent developments concerning their social cognition and why an integration of these areas would be beneficial to optimise the authors' interactions with the Norway rat is provided.
Journal ArticleDOI
Psycho-Neuroendocrine-Immune Interactions in COVID-19: Potential Impacts on Mental Health.
Ícaro Raony,Camila Saggioro de Figueiredo,Pablo Pandolfo,Elizabeth Giestal-de-Araujo,Elizabeth Giestal-de-Araujo,Priscilla Oliveira Silva Bomfim,Priscilla Oliveira Silva Bomfim,Priscilla Oliveira Silva Bomfim,Wilson Savino,Wilson Savino +9 more
TL;DR: The hypothesis that neuroendocrine-immune interactions may be involved in negative impacts of SARS-CoV-2 infection and social isolation on psychiatric issues is highlighted.
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Effects of Single Cage Housing on Stress, Cognitive, and Seizure Parameters in the Rat and Mouse Pilocarpine Models of Epilepsy.
Houria Manouze,Houria Manouze,Antoine Ghestem,Victoria Poillerat,Mohammed Bennis,Saadia Ba-M’hamed,Jean-Jacques Benoliel,Christel Becker,Christophe Bernard +8 more
TL;DR: It is proposed that social isolation produces a severe phenotype in terms of stress and seizure frequency as compared to animals maintaining social contact (at least in these two models), a factor that needs to be taken into account for data interpretation, in particular for preclinical studies.
References
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Nitric oxide: physiology, pathophysiology, and pharmacology
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The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
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Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
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More hippocampal neurons in adult mice living in an enriched environment
TL;DR: It is shown that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages, and that the enriched mice have a larger hippocampal granule cell layer and 15 per cent moregranule cell neurons in the Dentate Gyrus.
Journal ArticleDOI
Nitric oxide synthases: regulation and function.
TL;DR: Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS), which can be expressed in many cell types in response to lipopolysaccharide, cytokines, or other agents.