Journal ArticleDOI
Neuronal circuits of the neocortex
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TLDR
It is found that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought.Abstract:
We explore the extent to which neocortical circuits generalize, i.e., to what extent can neocortical neurons and the circuits they form be considered as canonical? We find that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Similarly, the inhibitory neurons show characteristic morphology and patterns of connections throughout the neocortex. We offer a simple model of cortical processing that is consistent with the major features of cortical circuits: The superficial layer neurons within local patches of cortex, and within areas, cooperate to explore all possible interpretations of different cortical input and cooperatively select an interpretation consistent with their various cortical and subcortical inputs.read more
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Anatomical and electrophysiological mechanisms for asymmetrical excitatory propagation in the rat insular cortex: in vivo optical imaging and whole-cell patch-clamp studies.
Kazunori Adachi,Kazunori Adachi,Satoshi Fujita,Atsushi Yoshida,Hiroshi Sakagami,Noriaki Koshikawa,Masayuki Kobayashi +6 more
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A dynamical systems framework to uncover the drivers of large-scale cortical activity
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Focal transcranial magnetic stimulation in awake rats: Enhanced glucose uptake in deep cortical layers
Samantha Cermak,Qinglei Meng,Kevin Peng,Simone Baldwin,Carlos A. Mejias-Aponte,Yihong Yang,Hanbing Lu +6 more
TL;DR: A method for performing TMS in awake rats and to characterize neuronal response to TMS by mapping glucose uptake following TMS administration, which allows for consistent motor threshold assessment for longitudinal studies.
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Multiple timescales account for adaptive responses across sensory cortices
Kenneth W. Latimer,Dylan Barbera,Michael Sokoletsky,Bshara Awwad,Yonatan Katz,Israel Nelken,Ilan Lampl,Adrienne L. Fairhall,Nicholas J. Priebe +8 more
TL;DR: This work measured the membrane potential responses of individual neurons in the visual, somatosensory and auditory cortices to discrete, punctate stimuli delivered at a wide range of fixed and nonfixed frequencies and finds that the adaptive profile of the response is largely preserved across these three areas.
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Microglia in the Primary Somatosensory Barrel Cortex Mediate Trigeminal Neuropathic Pain.
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References
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Receptive fields, binocular interaction and functional architecture in the cat's visual cortex
David H. Hubel,Torsten N. Wiesel +1 more
TL;DR: This method is used to examine receptive fields of a more complex type and to make additional observations on binocular interaction and this approach is necessary in order to understand the behaviour of individual cells, but it fails to deal with the problem of the relationship of one cell to its neighbours.
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Distributed Hierarchical Processing in the Primate Cerebral Cortex
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Hierarchical models of object recognition in cortex
TL;DR: A new hierarchical model consistent with physiological data from inferotemporal cortex that accounts for this complex visual task and makes testable predictions is described.
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Neuromorphic electronic systems
TL;DR: It is shown that for many problems, particularly those in which the input data are ill-conditioned and the computation can be specified in a relative manner, biological solutions are many orders of magnitude more effective than those using digital methods.
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