Journal ArticleDOI
Neuronal circuits of the neocortex
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TLDR
It is found that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought.Abstract:
We explore the extent to which neocortical circuits generalize, i.e., to what extent can neocortical neurons and the circuits they form be considered as canonical? We find that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Similarly, the inhibitory neurons show characteristic morphology and patterns of connections throughout the neocortex. We offer a simple model of cortical processing that is consistent with the major features of cortical circuits: The superficial layer neurons within local patches of cortex, and within areas, cooperate to explore all possible interpretations of different cortical input and cooperatively select an interpretation consistent with their various cortical and subcortical inputs.read more
Citations
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A million spiking-neuron integrated circuit with a scalable communication network and interface
Paul A. Merolla,John V. Arthur,Rodrigo Alvarez-Icaza,Andrew S. Cassidy,Jun Sawada,Filipp Akopyan,Bryan L. Jackson,Nabil Imam,Chen Guo,Yutaka Nakamura,Bernard Brezzo,Ivan Vo,Steven K. Esser,Rathinakumar Appuswamy,Brian Taba,Arnon Amir,Myron D. Flickner,William P. Risk,Rajit Manohar,Dharmendra S. Modha +19 more
TL;DR: Inspired by the brain’s structure, an efficient, scalable, and flexible non–von Neumann architecture is developed that leverages contemporary silicon technology and is well suited to many applications that use complex neural networks in real time, for example, multiobject detection and classification.
Journal ArticleDOI
What we can do and what we cannot do with fMRI
TL;DR: An overview of the current state of fMRI is given, and the current understanding of the haemodynamic signals and the constraints they impose on neuroimaging data interpretation are presented.
Journal ArticleDOI
An anatomically comprehensive atlas of the adult human brain transcriptome
Michael Hawrylycz,Ed S. Lein,Angela L. Guillozet-Bongaarts,Elaine H. Shen,Lydia Ng,Jeremy A. Miller,Louie N. van de Lagemaat,Kimberly A. Smith,Amanda Ebbert,Zackery L. Riley,Chris Abajian,Christian F. Beckmann,Amy Bernard,Darren Bertagnolli,Andrew F. Boe,Preston M. Cartagena,M. Mallar Chakravarty,Mike Chapin,Jimmy Chong,Rachel A. Dalley,Barry Daly,Chinh Dang,Suvro Datta,Nick Dee,Tim A. Dolbeare,Vance Faber,David Feng,David R. Fowler,Jeff Goldy,Benjamin W. Gregor,Zeb Haradon,David R. Haynor,John G. Hohmann,Steve Horvath,Robert Howard,Andreas Jeromin,Jayson M. Jochim,Marty Kinnunen,Christopher Lau,Evan T. Lazarz,Changkyu Lee,Tracy Lemon,Ling Li,Yang Li,John A. Morris,Caroline C. Overly,Patrick D. Parker,Sheana Parry,Melissa Reding,Joshua J. Royall,Jay Schulkin,Pedro Adolfo Sequeira,Clifford R. Slaughterbeck,Simon Smith,Andy J. Sodt,Susan M. Sunkin,Beryl Swanson,Marquis P. Vawter,Derric Williams,Paul Wohnoutka,H. Ronald Zielke,Daniel H. Geschwind,Patrick R. Hof,Stephen M. Smith,Christof Koch,Seth G. N. Grant,Allan R. Jones +66 more
TL;DR: A transcriptional atlas of the adult human brain is described, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals, to form a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.
Journal ArticleDOI
Canonical Microcircuits for Predictive Coding
André M. Bastos,William Martin Usrey,Rick A. Adams,George R. Mangun,Pascal Fries,Pascal Fries,Karl J. Friston +6 more
TL;DR: This analysis discloses a remarkable correspondence between the microcircuitry of the cortical column and the connectivity implied by predictive coding and provides some intuitive insights into the functional asymmetries between feedforward and feedback connections and the characteristic frequencies over which they operate.
Journal ArticleDOI
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
TL;DR: A plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention, and implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.
References
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Journal ArticleDOI
Laminar origins and terminations of cortical connections of the occipital lobe in the rhesus monkey.
TL;DR: Different cortical projection systems are characterized by specific laminar distributions of efferent terminations as well as of their neurons of origin.
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The visual field representation in striate cortex of the macaque monkey: Asymmetries, anisotropies, and individual variability
TL;DR: The topographic organization of striate cortex in the macaque was studied using physiological recording techniques as mentioned in this paper, which facilitated the quantitative analysis of various features of the visual representation, including individual variability in these features as well as in the overall size of the cortex.
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Functional specialisation in the visual cortex of the rhesus monkey
TL;DR: Anatomical and functional studies of the visual cortex of the rhesus monkey have shown that it is made up of a multiplicity of distinct areas that seem to be functionally specialised to analyse different features of thevisual environment.
Journal ArticleDOI
Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior
TL;DR: Common efferent projections of the dorsolateral prefrontal cortex and posterior parietal cortex were examined in 3 rhesus monkeys by placing injections of tritiated amino acids and HRP in frontal and parietal cortices, respectively, of the same hemisphere.
Journal ArticleDOI
Functional organization of thalamocortical relays
S. M. Sherman,R. W. Guillery +1 more
TL;DR: Although the specific function of the circuits and cellular properties of the thalamic relay for waking behavior is far from clear, two related hypotheses are offered based on recent experimental evidence: one is that theThalamus is not used just to relay peripheral information from, for example, visual, auditory, or cerebellar inputs, but that someThalamic nuclei are arranged instead to relay information from one cortical area to another.