Journal ArticleDOI
Neuronal circuits of the neocortex
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TLDR
It is found that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought.Abstract:
We explore the extent to which neocortical circuits generalize, i.e., to what extent can neocortical neurons and the circuits they form be considered as canonical? We find that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Similarly, the inhibitory neurons show characteristic morphology and patterns of connections throughout the neocortex. We offer a simple model of cortical processing that is consistent with the major features of cortical circuits: The superficial layer neurons within local patches of cortex, and within areas, cooperate to explore all possible interpretations of different cortical input and cooperatively select an interpretation consistent with their various cortical and subcortical inputs.read more
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Dissertation
Cortical Representation of Touch: from Whole Cell Recordings to Network Simulations in silico
TL;DR: It is shown that the sensory information is transferred from one locus to another with high fidelity even though there is a significant amount of information loss when a single neuron converts the information it received.
Journal ArticleDOI
Combined Phase-Rate Coding by Persistently Active Neurons as a Mechanism for Maintaining Multiple Items in Working Memory in Humans
TL;DR: A computational model is provided that reveals that inhibitory-feedback-mediated competition between multiple persistently active neurons reproduces this phenomenon of active maintenance of multiple items in WM.
Journal ArticleDOI
Virtual Electrode Recording Tool for EXtracellular potentials (VERTEX): comparing multi-electrode recordings from simulated and biological mammalian cortical tissue
Richard Tomsett,Richard Tomsett,Matt Ainsworth,Alexander Thiele,Mehdi Sanayei,Xing Chen,Marc Alwin Gieselmann,Miles A. Whittington,Mark O. Cunningham,Marcus Kaiser +9 more
TL;DR: The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) as discussed by the authors uses a reduced neuron model that retains the spatial and frequency filtering characteristics of extracellular potentials from neocortical neurons.
Journal ArticleDOI
A Role for Silent Synapses in the Development of the Pathway from Layer 2/3 to 5 Pyramidal Cells in the Neocortex
TL;DR: The integration of neurons within the developing cerebral cortex is a prolonged process dependent on a combination of molecular and physiological cues and laser scanning photostimulation of caged glutamate in conjunction with whole-cell patch-clamp electrophysiology to probe the integration of pyramidal cells in the sensorimotor regions of the mouse neocortex.
Journal ArticleDOI
Direction- and distance-dependent interareal connectivity of pyramidal cell subpopulations in the rat frontal cortex.
TL;DR: It is suggested that selective participation in iCC connections by pyramidal cell subtypes lead to directional connectivity between M2 and other cortical areas, and the interaction of local circuits with long-range interareal connections.
References
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Journal ArticleDOI
Receptive fields, binocular interaction and functional architecture in the cat's visual cortex
David H. Hubel,Torsten N. Wiesel +1 more
TL;DR: This method is used to examine receptive fields of a more complex type and to make additional observations on binocular interaction and this approach is necessary in order to understand the behaviour of individual cells, but it fails to deal with the problem of the relationship of one cell to its neighbours.
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Distributed Hierarchical Processing in the Primate Cerebral Cortex
TL;DR: A summary of the layout of cortical areas associated with vision and with other modalities, a computerized database for storing and representing large amounts of information on connectivity patterns, and the application of these data to the analysis of hierarchical organization of the cerebral cortex are reported on.
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Hierarchical models of object recognition in cortex
TL;DR: A new hierarchical model consistent with physiological data from inferotemporal cortex that accounts for this complex visual task and makes testable predictions is described.
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Neuromorphic electronic systems
TL;DR: It is shown that for many problems, particularly those in which the input data are ill-conditioned and the computation can be specified in a relative manner, biological solutions are many orders of magnitude more effective than those using digital methods.
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