Journal ArticleDOI
Neuronal circuits of the neocortex
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TLDR
It is found that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought.Abstract:
We explore the extent to which neocortical circuits generalize, i.e., to what extent can neocortical neurons and the circuits they form be considered as canonical? We find that, as has long been suspected by cortical neuroanatomists, the same basic laminar and tangential organization of the excitatory neurons of the neocortex is evident wherever it has been sought. Similarly, the inhibitory neurons show characteristic morphology and patterns of connections throughout the neocortex. We offer a simple model of cortical processing that is consistent with the major features of cortical circuits: The superficial layer neurons within local patches of cortex, and within areas, cooperate to explore all possible interpretations of different cortical input and cooperatively select an interpretation consistent with their various cortical and subcortical inputs.read more
Citations
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A million spiking-neuron integrated circuit with a scalable communication network and interface
Paul A. Merolla,John V. Arthur,Rodrigo Alvarez-Icaza,Andrew S. Cassidy,Jun Sawada,Filipp Akopyan,Bryan L. Jackson,Nabil Imam,Chen Guo,Yutaka Nakamura,Bernard Brezzo,Ivan Vo,Steven K. Esser,Rathinakumar Appuswamy,Brian Taba,Arnon Amir,Myron D. Flickner,William P. Risk,Rajit Manohar,Dharmendra S. Modha +19 more
TL;DR: Inspired by the brain’s structure, an efficient, scalable, and flexible non–von Neumann architecture is developed that leverages contemporary silicon technology and is well suited to many applications that use complex neural networks in real time, for example, multiobject detection and classification.
Journal ArticleDOI
What we can do and what we cannot do with fMRI
TL;DR: An overview of the current state of fMRI is given, and the current understanding of the haemodynamic signals and the constraints they impose on neuroimaging data interpretation are presented.
Journal ArticleDOI
An anatomically comprehensive atlas of the adult human brain transcriptome
Michael Hawrylycz,Ed S. Lein,Angela L. Guillozet-Bongaarts,Elaine H. Shen,Lydia Ng,Jeremy A. Miller,Louie N. van de Lagemaat,Kimberly A. Smith,Amanda Ebbert,Zackery L. Riley,Chris Abajian,Christian F. Beckmann,Amy Bernard,Darren Bertagnolli,Andrew F. Boe,Preston M. Cartagena,M. Mallar Chakravarty,Mike Chapin,Jimmy Chong,Rachel A. Dalley,Barry Daly,Chinh Dang,Suvro Datta,Nick Dee,Tim A. Dolbeare,Vance Faber,David Feng,David R. Fowler,Jeff Goldy,Benjamin W. Gregor,Zeb Haradon,David R. Haynor,John G. Hohmann,Steve Horvath,Robert Howard,Andreas Jeromin,Jayson M. Jochim,Marty Kinnunen,Christopher Lau,Evan T. Lazarz,Changkyu Lee,Tracy Lemon,Ling Li,Yang Li,John A. Morris,Caroline C. Overly,Patrick D. Parker,Sheana Parry,Melissa Reding,Joshua J. Royall,Jay Schulkin,Pedro Adolfo Sequeira,Clifford R. Slaughterbeck,Simon Smith,Andy J. Sodt,Susan M. Sunkin,Beryl Swanson,Marquis P. Vawter,Derric Williams,Paul Wohnoutka,H. Ronald Zielke,Daniel H. Geschwind,Patrick R. Hof,Stephen M. Smith,Christof Koch,Seth G. N. Grant,Allan R. Jones +66 more
TL;DR: A transcriptional atlas of the adult human brain is described, comprising extensive histological analysis and comprehensive microarray profiling of ∼900 neuroanatomically precise subdivisions in two individuals, to form a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function.
Journal ArticleDOI
Canonical Microcircuits for Predictive Coding
André M. Bastos,William Martin Usrey,Rick A. Adams,George R. Mangun,Pascal Fries,Pascal Fries,Karl J. Friston +6 more
TL;DR: This analysis discloses a remarkable correspondence between the microcircuitry of the cortical column and the connectivity implied by predictive coding and provides some intuitive insights into the functional asymmetries between feedforward and feedback connections and the characteristic frequencies over which they operate.
Journal ArticleDOI
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
TL;DR: A plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention, and implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.
References
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TL;DR: Each subtype of cells made GABAergic synapses onto relatively specific portions of cortical cells, but similar domains were innervated by multiple classes of GABA cells.
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Orientation Selectivity and the Arrangement of Horizontal Connections in Tree Shrew Striate Cortex
TL;DR: The results indicate that horizontal connections outside a radius of 500 μm from the injection site exhibit not only modular specificity, but also specificity for axis of projection, suggesting specific ways that horizontal circuits contribute to the response properties of layer 2/3 neurons and to mechanisms of visual perception.
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Columnar specificity of intrinsic horizontal and corticocortical connections in cat visual cortex
TL;DR: The extent of the horizontal connections, which allows single cells to integrate information over larger parts of the visual field than that covered by their receptive fields, and the functional specificity of the connections, suggests possible roles for these connections in visual processing.
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Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex.
Pasko Rakic,Jean-Pierre Bourgeois,Maryellen F. Eckenhoff,Nada Zecevic,Patricia S. Goldman-Rakic +4 more
TL;DR: This isochronic course of synaptogenesis in anatomically and functionally diverse regions indicates that the entire cerebral cortex develops as a whole and that the establishment of cell-to-cell communication in this structure may be orchestrated by a single genetic or humoral signal.
Journal ArticleDOI
Histologie du Système Nerveux de Lʼhomme et des Vertébrés
TL;DR: This ebook version of Histologie Du Systeme Nerveux de L'Homme Et Des Vertebres (French Edition) is presented in PDF, ePub, txt, doc, DjVu formats.