Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases.
Manovriti Thakur,Bryce R. Evans,Marc Schindewolf,Iris Baumgartner,Yvonne Döring,Yvonne Döring +5 more
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TLDR
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils.Abstract:
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils. NETs participate in host immune defense by entrapping pathogens. They are pro-inflammatory in function, and they act as an initiator of vascular coagulopathies by providing a platform for the attachment of various coagulatory proteins. NETs are diverse in their ability to alter physiological and pathological processes including infection and inflammation. In this review, we will summarize recent findings on the role of NETs in bacterial/viral infections associated with vascular inflammation, thrombosis, atherosclerosis and autoimmune disorders. Understanding the complex role of NETs in bridging infection and chronic inflammation as well as discussing important questions related to their contribution to pathologies outlined above may pave the way for future research on therapeutic targeting of NETs applicable to specific infections and inflammatory disorders.read more
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References
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Hepatitis B Virus Inhibits Neutrophil Extracellular Trap Release by Modulating Reactive Oxygen Species Production and Autophagy.
TL;DR: Overall, HBV may inhibit NET release by modulating reactive oxygen species production and autophagy to escape the immune system and promote the establishment of chronic infection.
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Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI.
Ragnhild Helseth,Christian Shetelig,Geir Øystein Andersen,Miriam Sjåstad Langseth,Miriam Sjåstad Langseth,Miriam Sjåstad Langseth,Shanmuganathan Limalanathan,Trine Baur Opstad,Trine Baur Opstad,Harald Arnesen,Harald Arnesen,Pavel Hoffmann,Jan Eritsland,Ingebjørg Seljeflot,Ingebjørg Seljeflot +14 more
TL;DR: High day 1 dsDNA levels after STEMI were associated with myocardial infarct size, adverse left ventricular remodeling, and clinical outcome, indicating a potential role for ds DNA in acute myocardIAL ischemia.
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SARS-CoV-2 Shedding from Asymptomatic Patients: Contribution of Potential Extrapulmonary Tissue Reservoirs.
TL;DR: The focus of this perspective is the extrapulmonary tissues affected by SARS-CoV-2 and the potential implications of their involvement for disease pathogenesis and the development of medical countermeasures.
Journal Article
Possible linkage between microscopic polyangiitis and thrombosis via neutrophil extracellular traps.
Teppei Imamoto,Daigo Nakazawa,Haruki Shida,Akira Suzuki,Noriyuki Otsuka,Utano Tomaru,Akihiro Ishizu +6 more
TL;DR: Possible linkage between microscopic polyangiitis and thrombosis through neutrophil extracellular traps via neutrophils via neutrophic traps is suggested.
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Characterization of influenza virus-induced leukocyte adherence to human umbilical vein endothelial cell monolayers.
TL;DR: Monitoring of adherence of undifferentiated 51Cr-labeled HL-60 cells on influenza virus-infected HUVEC monolayers suggests that virus-induced adherence is not a result of upregulation of E-selectin and ICAM-1, and appears that HL- 60 cells are binding directly to HA.