Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases.
Manovriti Thakur,Bryce R. Evans,Marc Schindewolf,Iris Baumgartner,Yvonne Döring,Yvonne Döring +5 more
Reads0
Chats0
TLDR
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils.Abstract:
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils. NETs participate in host immune defense by entrapping pathogens. They are pro-inflammatory in function, and they act as an initiator of vascular coagulopathies by providing a platform for the attachment of various coagulatory proteins. NETs are diverse in their ability to alter physiological and pathological processes including infection and inflammation. In this review, we will summarize recent findings on the role of NETs in bacterial/viral infections associated with vascular inflammation, thrombosis, atherosclerosis and autoimmune disorders. Understanding the complex role of NETs in bridging infection and chronic inflammation as well as discussing important questions related to their contribution to pathologies outlined above may pave the way for future research on therapeutic targeting of NETs applicable to specific infections and inflammatory disorders.read more
Citations
More filters
Journal ArticleDOI
Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19.
Panagiotis Theofilis,Marios Sagris,Alexios S. Antonopoulos,Evangelos Oikonomou,Costas Tsioufis,Dimitris Tousoulis +5 more
TL;DR: In this paper, the impact of inflammation on platelet activation in atherosclerosis has been investigated and the role of pro-inflammatory cytokines has also been highlighted, such as platelet factor-4, myeloperoxidase, and platelet-derived mediators.
Journal ArticleDOI
Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches
Panagiotis Theofilis,Marios Sagris,Evangelos Oikonomou,Alexios S. Antonopoulos,Constantinos Tsioufis,Dimitris Tousoulis +5 more
TL;DR: An overview of the available antiplatelet agents is being portrayed, together with agents possessing off-set platelet-inhibitory actions, while an extensive presentation of drugs under investigation is given.
Journal ArticleDOI
Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases.
Jiami Zou,Jiaojiao Wang,Weile Ye,Jing Lu,Cheng-Zhi Li,Dong-Mei Zhang,Wen-Cai Ye,Suowen Xu,Chunbo Chen,Peiqing Liu,Zhiping Liu +10 more
TL;DR: In this paper , the authors provide a rigorous and up-to-date overview of the cardiovascular protection properties and potential molecular targets of Citri Reticulatae Pericarpium (CRP), and highlight the pharmacokinetics and therapeutic potential of the main pharmacologically active components of CRP to treat CVDs.
References
More filters
Journal ArticleDOI
Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury: Implications for Superficial Erosion
Grégory Franck,Thomas L. Mawson,Eduardo J. Folco,Roberto Molinaro,Victoria Ruvkun,Daniel Engelbertsen,Xin Liu,Yevgenia Tesmenitsky,Eugenia Shvartz,Galina K. Sukhova,Jean-Baptiste Michel,Antonino Nicoletti,Andrew H. Lichtman,Denisa D. Wagner,Kevin Croce,Peter Libby +15 more
TL;DR: Results indicate that PAD4 from bone marrow-derived cells and NETs do not influence chronic experimental atherogenesis, but participate causally in acute thrombotic complications of intimal lesions that recapitulate features of superficial erosion.
Journal ArticleDOI
In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps.
Denis F. Noubouossie,Matthew F. Whelihan,Yuan Bin Yu,Erica M. Sparkenbaugh,Rafal Pawlinski,Dougald M. Monroe,Nigel S. Key +6 more
TL;DR: It is concluded that unlike DNA or individual histone proteins, human intact NETs do not directly initiate or amplify coagulation in vitro.
Journal ArticleDOI
The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)
Angélica Arcanjo,Jorgete Logullo,Camilla Cristie Barreto Menezes,Thais Chrispim de Souza Carvalho Giangiarulo,Mirella Carneiro dos Reis,Gabriellen Menezes Migliani de Castro,Yasmin da Silva Fontes,Adriane R. Todeschini,Leonardo Freire-de-Lima,Debora Decote-Ricardo,Antonio Ferreira-Pereira,Celio Geraldo Freire-de-Lima,Shana Priscila Coutinho Barroso,Christina Maeda Takiya,Fátima Conceição-Silva,Wilson Savino,Wilson Savino,Alexandre Morrot,Alexandre Morrot +18 more
TL;DR: It is demonstrated for the first time that SARS-CoV-2 in fact is able to activate NETosis in human neutrophils, and the findings indicated that this process is associated with increased levels of intracellular Reactive Oxygen Species (ROS) in neutrophilia, which plays a role in thrombosis formation.
Journal ArticleDOI
Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes
Andrea Valle,Gian Maria Giamporcaro,Marina Scavini,Angela Stabilini,Pauline Grogan,Eleonora Bianconi,Guido Sebastiani,Matilde Masini,Norma Maugeri,Laura Porretti,Riccardo Bonfanti,Franco Meschi,Maurizio De Pellegrin,Arianna Lesma,Silvano Rossini,Lorenzo Piemonti,Piero Marchetti,Francesco Dotta,Emanuele Bosi,Manuela Battaglia +19 more
TL;DR: The existence of a hitherto unrecognized clinical phenotype that might reflect unexplored pathogenic pathways underlying T1D is suggested, and it is suggested that pancreas-infiltrating neutrophils mainly localized at the level of very small blood vessels are responsible for this reduction.
Journal ArticleDOI
Blood coagulation in immunothrombosis-At the frontline of intravascular immunity.
TL;DR: The cellular and molecular events that initiate fibrin formation during the innate immune response are summarized and how aberrant activation of these pathways fosters pathologies associated with thrombosis are discussed, including disseminated intravascular coagulation and atherothromBosis.