Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases.
Manovriti Thakur,Bryce R. Evans,Marc Schindewolf,Iris Baumgartner,Yvonne Döring,Yvonne Döring +5 more
Reads0
Chats0
TLDR
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils.Abstract:
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils. NETs participate in host immune defense by entrapping pathogens. They are pro-inflammatory in function, and they act as an initiator of vascular coagulopathies by providing a platform for the attachment of various coagulatory proteins. NETs are diverse in their ability to alter physiological and pathological processes including infection and inflammation. In this review, we will summarize recent findings on the role of NETs in bacterial/viral infections associated with vascular inflammation, thrombosis, atherosclerosis and autoimmune disorders. Understanding the complex role of NETs in bridging infection and chronic inflammation as well as discussing important questions related to their contribution to pathologies outlined above may pave the way for future research on therapeutic targeting of NETs applicable to specific infections and inflammatory disorders.read more
Citations
More filters
Journal ArticleDOI
Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19.
Panagiotis Theofilis,Marios Sagris,Alexios S. Antonopoulos,Evangelos Oikonomou,Costas Tsioufis,Dimitris Tousoulis +5 more
TL;DR: In this paper, the impact of inflammation on platelet activation in atherosclerosis has been investigated and the role of pro-inflammatory cytokines has also been highlighted, such as platelet factor-4, myeloperoxidase, and platelet-derived mediators.
Journal ArticleDOI
Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches
Panagiotis Theofilis,Marios Sagris,Evangelos Oikonomou,Alexios S. Antonopoulos,Constantinos Tsioufis,Dimitris Tousoulis +5 more
TL;DR: An overview of the available antiplatelet agents is being portrayed, together with agents possessing off-set platelet-inhibitory actions, while an extensive presentation of drugs under investigation is given.
Journal ArticleDOI
Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases.
Jiami Zou,Jiaojiao Wang,Weile Ye,Jing Lu,Cheng-Zhi Li,Dong-Mei Zhang,Wen-Cai Ye,Suowen Xu,Chunbo Chen,Peiqing Liu,Zhiping Liu +10 more
TL;DR: In this paper , the authors provide a rigorous and up-to-date overview of the cardiovascular protection properties and potential molecular targets of Citri Reticulatae Pericarpium (CRP), and highlight the pharmacokinetics and therapeutic potential of the main pharmacologically active components of CRP to treat CVDs.
References
More filters
Journal ArticleDOI
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A).
Eleni Frangou,Akrivi Chrysanthopoulou,Alexandros Mitsios,Konstantinos Kambas,Stella Arelaki,Iliana Angelidou,Athanasios Arampatzioglou,Hariklia Gakiopoulou,George Bertsias,Panayotis Verginis,Konstantinos Ritis,Dimitrios T. Boumpas +11 more
TL;DR: Autophagy-mediated release of TF-bearing and IL-17A-bearing NETs provides a link between thromboinflammation and fibrosis in SLE and may account for the salutary effects of hydroxychloroquine.
Journal ArticleDOI
Peptidylarginine deiminase 4 promotes age-related organ fibrosis
Kimberly Martinod,Kimberly Martinod,Thilo Witsch,Thilo Witsch,Luise Erpenbeck,Luise Erpenbeck,Alexander Savchenko,Alexander Savchenko,Hideki Hayashi,Hideki Hayashi,Deya Cherpokova,Deya Cherpokova,Maureen Gallant,Maximilian Mauler,Stephen M. Cifuni,Denisa D. Wagner,Denisa D. Wagner +16 more
TL;DR: It is concluded that PAD4 regulates age-related organ fibrosis and dysfunction and proposes a role for NETs in cardiac fibrosis, and DNase 1 was given to assess the effects of extracellular chromatin.
Journal ArticleDOI
The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction
Giuseppe Lo Sasso,Walter K. Schlage,Stéphanie Boué,Emilija Veljkovic,Manuel C. Peitsch,Julia Hoeng +5 more
TL;DR: The suitability of this animal model for researching the effects of cigarette smoking on atherosclerosis and emphysema is highlighted, with a particular focus on work conducted in the context of cigarette smoke inhalation studies.
Journal ArticleDOI
Mechanisms of Premature Atherosclerosis in Rheumatoid Arthritis and Lupus
TL;DR: This review focuses on analyzing the major mechanisms and pathways potentially implicated in the acceleration of atherothrombosis and CV risk in SLE and RA, as well as in the identification of putative preventive strategies that may mitigate vascular complications in systemic autoimmunity.
Journal ArticleDOI
Risk for Myocardial Infarction and Stroke after Community-Acquired Bacteremia: A 20-Year Population-Based Cohort Study
Michael Dalager-Pedersen,Mette Søgaard,Henrik Carl Schønheyder,Henrik Nielsen,Reimar W. Thomsen +4 more
TL;DR: In this paper, the risk for acute myocardial infarction and ischemic stroke within 1 year of community-acquired bacteremia was assessed in Northern Denmark.