Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases.
Manovriti Thakur,Bryce R. Evans,Marc Schindewolf,Iris Baumgartner,Yvonne Döring,Yvonne Döring +5 more
Reads0
Chats0
TLDR
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils.Abstract:
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils. NETs participate in host immune defense by entrapping pathogens. They are pro-inflammatory in function, and they act as an initiator of vascular coagulopathies by providing a platform for the attachment of various coagulatory proteins. NETs are diverse in their ability to alter physiological and pathological processes including infection and inflammation. In this review, we will summarize recent findings on the role of NETs in bacterial/viral infections associated with vascular inflammation, thrombosis, atherosclerosis and autoimmune disorders. Understanding the complex role of NETs in bridging infection and chronic inflammation as well as discussing important questions related to their contribution to pathologies outlined above may pave the way for future research on therapeutic targeting of NETs applicable to specific infections and inflammatory disorders.read more
Citations
More filters
Journal ArticleDOI
Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19.
Panagiotis Theofilis,Marios Sagris,Alexios S. Antonopoulos,Evangelos Oikonomou,Costas Tsioufis,Dimitris Tousoulis +5 more
TL;DR: In this paper, the impact of inflammation on platelet activation in atherosclerosis has been investigated and the role of pro-inflammatory cytokines has also been highlighted, such as platelet factor-4, myeloperoxidase, and platelet-derived mediators.
Journal ArticleDOI
Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches
Panagiotis Theofilis,Marios Sagris,Evangelos Oikonomou,Alexios S. Antonopoulos,Constantinos Tsioufis,Dimitris Tousoulis +5 more
TL;DR: An overview of the available antiplatelet agents is being portrayed, together with agents possessing off-set platelet-inhibitory actions, while an extensive presentation of drugs under investigation is given.
Journal ArticleDOI
Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases.
Jiami Zou,Jiaojiao Wang,Weile Ye,Jing Lu,Cheng-Zhi Li,Dong-Mei Zhang,Wen-Cai Ye,Suowen Xu,Chunbo Chen,Peiqing Liu,Zhiping Liu +10 more
TL;DR: In this paper , the authors provide a rigorous and up-to-date overview of the cardiovascular protection properties and potential molecular targets of Citri Reticulatae Pericarpium (CRP), and highlight the pharmacokinetics and therapeutic potential of the main pharmacologically active components of CRP to treat CVDs.
References
More filters
Journal ArticleDOI
Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease.
TL;DR: Neutrophils are primary effector cells of innate immunity and fight infection by phagocytosis and degranulation. Activated neutrophils also release neutrophil extracellular traps (NETs) in response to a variety of stimuli.
Journal ArticleDOI
Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge–Mediated Monocyte Adhesion
Ariane Schumski,Almudena Ortega-Gomez,Kanin Wichapong,Carla Winter,Patricia Lemnitzer,Joana R. Viola,Mayra Pinilla-Vera,Eduardo J. Folco,Victor Solis-Mezarino,Moritz Völker-Albert,Sanne L. Maas,Chang Pan,Laura Perez Olivares,Janine Winter,Tilman M. Hackeng,Mikael C. I. Karlsson,Tanja Zeller,Axel Imhof,Rebecca M. Baron,Gerry A. F. Nicolaes,Peter Libby,Lars Maegdefessel,Frits Kamp,Martin Benoit,Yvonne Döring,Yvonne Döring,Oliver Soehnlein,Oliver Soehnlein +27 more
TL;DR: It is shown that NET-associated histone H2a mediates charge-dependent monocyte adhesion to NETs and accelerates atherosclerosis during endotoxinemia.
Journal ArticleDOI
Influenza virus directly infects, inflames, and resides in the arteries of atherosclerotic and normal mice
Mehran Haidari,Philip R. Wyde,Silvio H. Litovsky,Silvio H. Litovsky,Deborah Vela,Deborah Vela,Muzammil Ali,S. Ward Casscells,S. Ward Casscells,Mohammad Madjid,Mohammad Madjid,Mohammad Madjid +11 more
TL;DR: It is shown for the first time that influenza virus can directly infect and reside in atherosclerotic arteries and that infection was associated with systemic and arterial-level pro-inflammatory changes.
Journal ArticleDOI
Reduced expression of CD44 on monocytes and neutrophils in systemic lupus erythematosus: relations with apoptotic neutrophils and disease activity
TL;DR: Monocyte and neutrophil CD44 expression is reduced in SLE, and this may contribute to the impaired recognition and clearance of apoptotic neutrophils by monocyte derived macrophages.
Journal ArticleDOI
Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis.
Yudong Liu,Carmelo Carmona-Rivera,Erica Moore,Nickie L Seto,Jason S. Knight,Milton Pryor,Zhi-Hong Yang,Saskia Hemmers,Alan T. Remaley,Kerri A. Mowen,Mariana J. Kaplan +10 more
TL;DR: The notion that NETs promote atherosclerosis and that the use of specific PAD4 inhibitors may have therapeutic benefits in this potentially devastating condition is supported.