New approaches to male non-hormonal contraception.
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TLDR
This review will focus on the use of lonidamine derivatives and inhibitors of retinoic acid biosynthesis and function as approaches to male non-hormonal contraception.About:
This article is published in Contraception.The article was published on 2013-03-01 and is currently open access. It has received 30 citations till now. The article focuses on the topics: Adjudin & Retinoic acid receptor.read more
Citations
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Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Ernst Schönbrunn,Stephane Betzi,R. Alam,Mathew P. Martin,Andreas Becker,Huijong Han,Rawle Francis,Ramappa Chakrasali,Sudhakar Jakkaraj,Aslamuzzaman Kazi,Said M. Sebti,Christopher L. Cubitt,Anthony W. Gebhard,Lori A. Hazlehurst,Joseph S. Tash,Gunda I. Georg +15 more
TL;DR: The development of highly potent diaminothiazole inhibitors of CDK2 from a single hit compound with weak inhibitory activity is described by high-throughput screening, demonstrating the potential of this new inhibitors series for further development into CDK-specific chemical probes or therapeutics.
Journal ArticleDOI
Metabolic cooperation in testis as a pharmacological target: from disease to contraception.
TL;DR: The metabolic cooperation in testis is discussed as a potential pharmacological target to counteract subfertility/infertility promoted by several diseases, particularly metabolic diseases.
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Male contraception: another Holy Grail.
Fern E. Murdoch,Erwin Goldberg +1 more
TL;DR: Research into the development of non-hormonal contraception for men is progressing in several laboratories and this will be the subject of the present review.
Journal ArticleDOI
Development of Novel Male Contraceptives.
TL;DR: The pros and cons of condoms and vasectomies are discussed, the research into novel methods of male contraception is reviewed, and work to develop novel male contraceptives analogous to popular female methods is underway.
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Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility.
Chien-Yu Lin,Chun-Yu Chen,Chih-Hsiang Yu,I-Shing Yu,Shu-Rung Lin,June-Tai Wu,Ying Hung Lin,Pao Lin Kuo,Jui-ching Wu,Shu-Wha Lin +9 more
TL;DR: X-linked CUL4B appears to play a critical role in acrosomal formation, nuclear condensation, and in regulating histone dynamics during haploid male germ cell differentiation in relation to male fertility in mice.
References
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Tissue changes following deprivation of fat-soluble a vitamin
S. Burt Wolbach,Percy R. Howe +1 more
TL;DR: The specific tissue changes which follow the deprivation of fat-soluble vitamin A in albino white rats and in the human concerns epithelial tissues are described and it is concluded that the deficiency results in loss of specific (chemical) functions of the epitheliums concerned, while the power of growth becomes augmented.
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Retinoic acid regulates sex-specific timing of meiotic initiation in mice.
TL;DR: In this paper, the authors examined the mechanism underlying the sex-specific timing of Stra8 expression and meiotic initiation in mice and showed that signaling by retinoic acid (RA), an active derivative of vitamin A, is required for Stra8expression and thereby meiosis initiation in embryonic ovaries.
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Unintended Pregnancy: Worldwide Levels, Trends, and Outcomes
TL;DR: The incidence of pregnancy by intention status and outcome at worldwide, regional, and subregional levels for 2008 is estimated, and recent trends since 1995 are assessed.
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Function of retinoic acid receptor γ in the mouse
David Lohnes,Philippe Kastner,Philippe Kastner,Andrée Dierich,Andrée Dierich,Manuel Mark,Manuel Mark,Marianne LeMeur,Marianne LeMeur,Pierre Chambon,Pierre Chambon +10 more
TL;DR: The observed RARγ null phenotype suggests a high degree of functional redundancy among the RARs, and the variable penetrance of some of the observed defects is discussed in light of this redundancy and stochastic variation of gene activity.
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High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice.
Thomas Lufkin,David Lohnes,Manuel Mark,Andrée Dierich,Philippe Gorry,Marie-Pierre Gaub,Marianne LeMeur,Pierre Chambon +7 more
TL;DR: Results, showing that RAR alpha is indeed involved in the transduction of the RA signal, also suggest an unexpected genetic redundancy.