Journal ArticleDOI
New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1.
Keiko Ogawa,Seikou Nakamura,Kohei Hosokawa,Hanako Ishimaru,Natsuki Saito,Kaori Ryu,Masahiro Fujimuro,Souichi Nakashima,Hisashi Matsuda +8 more
TLDR
The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations and the antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are evaluated.Abstract:
Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were isolated. The structural determination of new compounds damasterpenes V–VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.read more
Citations
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Journal ArticleDOI
Potential of diterpene compounds as antivirals, a review.
Andika Pramudya Wardana,Nanik Siti Aminah,Mila Rosyda,Muhammad Ikhlas Abdjan,Alfinda Novi Kristanti,Khun Nay Win Tun,Muhammad Iqbal Choudhary,Muhammad Iqbal Choudhary,Yoshiaki Takaya,Yoshiaki Takaya +9 more
TL;DR: In this paper, different types of diterpenes such as daphnane, tiglilane, kaurane, abietane, pimarane, labdane, dollabelane, jatrophane, dolastane, prenylated guaiane, tonantzitlolone, casbane, have antivirus activity.
Journal ArticleDOI
Immunomodulators for curtailing COVID-19: a positive approach
TL;DR: Assessment of immune enhancing herbs in this paper suggests that herbal medicines have proven beneficial against various dreadful viral infections and may definitely be helpful for the body to fight COVID-19 infection.
Journal ArticleDOI
Ligand- and structure-based virtual screening of Lamiaceae diterpenes with potential activity against a novel coronavirus (2019-nCoV)
Gabriela Cristina Soares Rodrigues,Mayara Dos Santos Maia,Renata Priscila Barros de Menezes,Andreza Barbosa Silva Cavalcanti,Natália Ferreira de Sousa,Érika Paiva de Moura,Luciana Scotti,Marcus Tullius Scotti +7 more
TL;DR: This study aimed to use computational methods to perform a virtual screen (VS) of candidate diterpenes with the potential to act as CoV inhibitors, and selected 19 compounds, including isotanshinone IIA, tanshinlactone, and tanshinketolactone which did not present toxicity within the evaluated parameters.
Book ChapterDOI
Analysis of diterpenes and diterpenoids
TL;DR: In this article, the properties and classification of diterpenes, importance of chromatography in diterphenes analysis, effects of processing in the phytochemicals have been discussed.
Journal ArticleDOI
Antimicrobial Diterpenes: Recent Development From Natural Sources
TL;DR: In this article , a systematic review of the literature regarding different classes of natural diterpenes and diterpoids with significant antibacterial, antifungal, antiviral, and antiprotozoal activities along with their reported structure-activity relationships is presented.
References
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Journal ArticleDOI
Resistance of Herpes Simplex Viruses to Nucleoside Analogues: Mechanisms, Prevalence, and Management
Jocelyne Piret,Guy Boivin +1 more
TL;DR: The gold standard phenotypic method for evaluating the susceptibility of HSV isolates to antiviral drugs is the plaque reduction assay and there is a need to develop new antiherpetic compounds with different mechanisms of action.
Journal ArticleDOI
New strategies against drug resistance to herpes simplex virus
TL;DR: Current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules and new antiviral mechanisms to fight the drug resistance of HSV are summarized.
Journal ArticleDOI
A chiroptical method for determining the absolute configuration of allylic alcohols
Journal ArticleDOI
In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii.
Jussara P. Barbosa,Renato Crespo Pereira,Juliana L. Abrantes,Claudio Cesar Cirne Santos,M. A. Rebello,Izabel C.P.P. Frugulhetti,Valéria Laneuville Teixeira +6 more
TL;DR: Three substances of Dictyota pfaffii afforded the rare dolabellane diterpene 10,18-diacetoxy-8-hydroxy-2, 6-dolABelladiene and the new 10-acetoxy-7,8-di-Hydroxy- 2,6-Dolablladiene, which showed strong anti-HSV-1 activity in vitro but only 3 inhibited the reverse transcriptase enzyme of HIV-
Journal ArticleDOI
Anti-herpes virus type 1 activity of oleanane-type triterpenoids.
Tsuyoshi Ikeda,Kazumi Yokomizo,Masafumi Okawa,Ryota Tsuchihashi,Junei Kinjo,Toshihiro Nohara,Masaru Uyeda +6 more
TL;DR: The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed.