Journal ArticleDOI
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
Reads0
Chats0
TLDR
Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.Abstract:
▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an exciting and active area of study. The involvement of NF-κB in the expression of numerous cytokines and adhesion molecules has supported its role as an evolutionarily conserved coordinating element in the organism's response to situations of infection, stress, and injury. Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-κB:IκB complex in the cytosol. The field now awaits the discovery and characterization of the kinase responsible for the inducible phosphorylation of IκB proteins. Another exciting development has been the demonstration that in certain situations NF-κB acts as an anti-apoptotic protein; therefore, elucidation of the mechanism by which NF-κB protects against cell death is an important goal. Finally, the generation of knockouts of members of the NF-κB/IκB family has allowed the study of the roles of these protein...read more
Citations
More filters
Journal ArticleDOI
Leukocyte Recruitment and the Acute Inflammatory Response
Paul Kubes,Peter A. Ward +1 more
TL;DR: This review summarizes the generally accepted paradigm of leukocyte recruitment based on studies using intravital microscopy to visualize the microcirculation based on the role of selectins and α4‐integrin as well as integrin‐mediated adhesion and some discussion of mechanisms by which the inflammatory response may be terminated.
Journal ArticleDOI
PPAR Regulation of Inflammatory Signaling in CNS Diseases.
TL;DR: Current knowledge on how PPARs regulate neuroinflammatory signaling networks in CNS diseases is reviewed, finding that PPAR agonists mitigate CNS disease by modulating inflammatory signaling network in immune cells.
Journal ArticleDOI
LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-κB
TL;DR: The data demonstrate for the first time that HSP70 overexpression with adenovirus injection prevented the LPS-induced increase in TNF-α and IL-6 levels in rats, and concludes that the effects of heat stress- induced increase in HSP 70 protein expression on LPS -induced cytokine elaboration in whole animals can be reproduced by the actions of a single gene product.
Journal ArticleDOI
Role of NF-κB in thyroid cancer
TL;DR: The results obtained suggest that targeting NF-kappaB could be a promising strategy for advanced thyroid cancer treatment, especially in combination with radio- or chemo-therapy.
Journal ArticleDOI
Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells
Emmanuelle Bensaude,Jane L. E. Turner,P. R. Wakeley,David A. Sweetman,Claire Pardieu,Trevor W. Drew,Thomas Wileman,Penelope P. Powell +7 more
TL;DR: CSFV can actively block anti-viral and apoptotic responses and this may contribute to virus persistence and point to a central role for infection of vascular endothelial cells during the pathogenesis of the disease, where a proinflammatory and procoagulant endothelium induced by the virus may disrupt the haemostatic balance and lead to the coagulation and thrombosis seen in acute disease.
References
More filters
Journal ArticleDOI
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
Journal ArticleDOI
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.
Journal ArticleDOI
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Amer A. Beg,David Baltimore +1 more
TL;DR: Reintroduction of RelA into RelA−/− fibroblasts resulted in enhanced survival, demonstrating that the presence ofrelA is required for protection from TNF-α.
Journal ArticleDOI
The acute phase response
Heinz Baumann,Jack Gauldie +1 more
TL;DR: This review outlines the principal cellular and molecular mechanisms that control initiation of the tissue response at the site of injury, the recruitment of the systemic defense mechanisms, the acute phase response of the liver and the resolution of the acutephase response.
Related Papers (5)
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Michael Karin,Yinon Ben-Neriah +1 more