Journal ArticleDOI
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
Reads0
Chats0
TLDR
Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.Abstract:
▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an exciting and active area of study. The involvement of NF-κB in the expression of numerous cytokines and adhesion molecules has supported its role as an evolutionarily conserved coordinating element in the organism's response to situations of infection, stress, and injury. Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-κB:IκB complex in the cytosol. The field now awaits the discovery and characterization of the kinase responsible for the inducible phosphorylation of IκB proteins. Another exciting development has been the demonstration that in certain situations NF-κB acts as an anti-apoptotic protein; therefore, elucidation of the mechanism by which NF-κB protects against cell death is an important goal. Finally, the generation of knockouts of members of the NF-κB/IκB family has allowed the study of the roles of these protein...read more
Citations
More filters
Journal ArticleDOI
An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways
Naohiro Inohara,Takeyoshi Koseki,Jingmei Lin,Luis del Peso,Peter C. Lucas,Felicia F. Chen,Yasunori Ogura,Gabriel Núñez +7 more
TL;DR: The proximity of RICK, RIP, and IKK complexes may play an important role for NF-kappaB activation during Nod1 oligomerization or trimerization of the tumor necrosis factor alpha receptor.
Journal ArticleDOI
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
Sydney Shall,Gilbert de Murcia +1 more
TL;DR: The present review summarizes the recent data obtained with the three PARP knockout mice in comparison with the chemical inhibitor approach, and reveals the instrumental role of PARP-1 in cell death after ischemia-reperfusion injury and in various inflammation process.
Journal ArticleDOI
Mechanisms of Neurodegeneration and Regeneration in Alcoholism
Fulton T. Crews,Kim Nixon +1 more
TL;DR: Abstinence after binge ethanol intoxication results in brain cell genesis that could contribute to the return of brain function and structure found in abstinent humans.
Journal ArticleDOI
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
TL;DR: Brd4 is identified as a novel coactivator of NF-κB through specifically binding to acetylated lysine-310 of RelA, and a mechanism by which acetylation of the RelA subunit stimulates the transcriptional activity of NF -κB and the NF-σκB-dependent inflammatory response is revealed.
Journal ArticleDOI
Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37
Neeloffer Mookherjee,Kelly L. Brown,Dawn M. E. Bowdish,Silvana Doria,Reza Falsafi,Karsten Hokamp,Fiona M. Roche,Ruixia Mu,Gregory H. Doho,Jelena Pistolic,Jon-Paul S. Powers,Jenny Bryan,Fiona S. L. Brinkman,Robert E. W. Hancock +13 more
TL;DR: It is proposed that the natural human host defense peptide LL-37 plays roles in the delicate balancing of inflammatory responses in homeostasis as well as in combating sepsis induced by certain TLR agonists.
References
More filters
Journal ArticleDOI
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
TL;DR: The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases.
Journal ArticleDOI
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
TL;DR: The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
Journal ArticleDOI
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
TL;DR: It is shown that mutations in the Toll signaling pathway dramatically reduce survival after fungal infection and the intracellular components of the dorsoventral signaling pathway and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults.
Journal ArticleDOI
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Amer A. Beg,David Baltimore +1 more
TL;DR: Reintroduction of RelA into RelA−/− fibroblasts resulted in enhanced survival, demonstrating that the presence ofrelA is required for protection from TNF-α.
Journal ArticleDOI
The acute phase response
Heinz Baumann,Jack Gauldie +1 more
TL;DR: This review outlines the principal cellular and molecular mechanisms that control initiation of the tissue response at the site of injury, the recruitment of the systemic defense mechanisms, the acute phase response of the liver and the resolution of the acutephase response.
Related Papers (5)
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Michael Karin,Yinon Ben-Neriah +1 more