Journal ArticleDOI
Alternatively spliced isoforms of the NMDARI receptor subunit.
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TLDR
The finding of cell-specific expression and developmental regulation of NRI splice variants, and of the NR2 subunits, provides an explanation for the diversity of properties of NMDA receptors in different neuronal populations.About:
This article is published in Trends in Neurosciences.The article was published on 1995-07-01. It has received 454 citations till now. The article focuses on the topics: Alternative splicing & Exonic splicing enhancer.read more
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The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
C. Geoffrey Lau,R. Suzanne Zukin +1 more
TL;DR: An emerging concept is that activity-dependent, bidirectional regulation of NMDAR trafficking provides a dynamic and potentially powerful mechanism for the regulation of synaptic efficacy and remodelling, which, if dysregulated, can contribute to neuropsychiatric disorders such as cocaine addiction, Alzheimer's disease and schizophrenia.
Journal ArticleDOI
Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity.
TL;DR: The importance of Ca(2+) regulation in mammalian neurons and the excitotoxicity hypothesis is summarized, and the molecular determinants of glutamate receptor-mediated excitOToxic mechanisms are focused on.
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The role of excitotoxicity in neurodegenerative disease: implications for therapy.
TL;DR: There now seems to be little doubt that such a process is indeed a determining factor in the extent of the lesions observed, and direct evidence for a pathogenic role for excitotoxicity in neurological disease is missing.
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Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors.
Stefano Vicini,Jian Feng Wang,Jin Hong Li,Wei Jian Zhu,Yue Hua Wang,Jianhong Luo,Barry B. Wolfe,Dennis R. Grayson +7 more
TL;DR: Channel deactivation was fast and comparable among receptors obtained by cotransfecting five distinct spliced variants of the NR1 subunit, each with the NR2A subunits, and recovery from desensitization was slower for NR1/NR2B than for NR2/NR3 channels, suggesting mechanisms additional to subunit composition may also regulate deactivation time course.
References
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Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
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Magnesium gates glutamate-activated channels in mouse central neurones
TL;DR: The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.
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Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
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Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
Hannah Monyer,Rolf Sprengel,Ralf Schoepfer,Anne Herb,Miyoko Higuchi,Hilda Lomelí,Nail Burnashev,Bert Sakmann,Peter H. Seeburg +8 more
TL;DR: Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% ientical in sequence, and these are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor sub Units.