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NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
C. Geoffrey Lau,R. Suzanne Zukin +1 more
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TLDR
An emerging concept is that activity-dependent, bidirectional regulation of NMDAR trafficking provides a dynamic and potentially powerful mechanism for the regulation of synaptic efficacy and remodelling, which, if dysregulated, can contribute to neuropsychiatric disorders such as cocaine addiction, Alzheimer's disease and schizophrenia.Abstract:
The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronal activity and sensory experience. Neuronal activity drives not only NMDAR synaptic targeting and incorporation, but also receptor retrieval, differential sorting into the endosomal-lysosomal pathway and lateral diffusion between synaptic and extrasynaptic sites. An emerging concept is that activity-dependent, bidirectional regulation of NMDAR trafficking provides a dynamic and potentially powerful mechanism for the regulation of synaptic efficacy and remodelling, which, if dysregulated, can contribute to neuropsychiatric disorders such as cocaine addiction, Alzheimer's disease and schizophrenia.read more
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Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
TL;DR: The major triggers that initiate and maintain central sensitization in healthy individuals in response to nociceptor input and in patients with inflammatory and neuropathic pain are reviewed, emphasizing the fundamental contribution and multiple mechanisms of synaptic plasticity caused by changes in the density, nature, and properties of ionotropic and metabotropic glutamate receptors.
Journal ArticleDOI
Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
Josep Dalmau,Amy J. Gleichman,Ethan G. Hughes,Jeffrey E. Rossi,Xiaoyu Peng,Meizan Lai,Scott K. Dessain,Myrna R. Rosenfeld,Rita J. Balice-Gordon,David A. Lynch,David A. Lynch +10 more
TL;DR: A well-defined set of clinical characteristics are associated with anti-NMDA-receptor encephalitis and the pathogenesis of the disorder seems to be mediated by antibodies.
Journal ArticleDOI
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
TL;DR: The effects of subunit composition on NMDAR properties, synaptic plasticity and cellular mechanisms implicated in neuropsychiatric disorders are reviewed and could provide new therapeutic strategies against dysfunctions of glutamatergic transmission.
Journal ArticleDOI
Synaptic plasticity and addiction
Julie A. Kauer,Robert C. Malenka +1 more
TL;DR: Accumulated evidence that drugs of abuse can hijack synaptic plasticity mechanisms in key brain circuits, most importantly in the mesolimbic dopamine system, which is central to reward processing in the brain is presented.
Journal ArticleDOI
Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring
TL;DR: It is argued that this neurobiological mechanism can explain failures of self-monitoring, leading to a mechanistic explanation for first-rank symptoms as pathognomonic features of schizophrenia, and may provide a basis for future diagnostic classifications with physiologically defined patient subgroups.
References
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TL;DR: A simple model is described that unifies much of the data that previously were viewed as contradictory about the molecular mechanisms of this long-lasting increase in synaptic strength in the hippocampus.
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AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.