Journal ArticleDOI
Nomograms for Predicting Local Recurrence, Distant Metastases, and Overall Survival for Patients With Locally Advanced Rectal Cancer on the Basis of European Randomized Clinical Trials
Vincenzo Valentini,Ruud G.P.M. van Stiphout,Guido Lammering,Maria Antonietta Gambacorta,M.C. Barba,Marek Bębenek,Franck Bonnetain,Jean François Bosset,Krzysztof Bujko,Luca Cionini,Jean Pierre Gerard,Claus Rödel,Aldo Sainato,Rolf Sauer,Bruce D. Minsky,Laurence Collette,Philippe Lambin +16 more
Reads0
Chats0
TLDR
The easy-to-use nomograms can predict LR, DM, and OS over a 5-year period after surgery and may be used as decision support tools in future trials by using the three defined risk groups to select patients for postoperative chemotherapy and close follow-up.Abstract:
Purpose The purpose of this study was to develop accurate models and nomograms to predict local recurrence, distant metastases, and survival for patients with locally advanced rectal cancer treated with long-course chemoradiotherapy (CRT) followed by surgery and to allow for a selection of patients who may benefit most from postoperative adjuvant chemotherapy and close follow-up. Patients and Methods All data (N = 2,795) from five major European clinical trials for rectal cancer were pooled and used to perform an extensive survival analysis and to develop multivariate nomograms based on Cox regression. Data from one trial was used as an external validation set. The variables used in the analysis were sex, age, clinical tumor stage stage, tumor location, radiotherapy dose, concurrent and adjuvant chemotherapy, surgery procedure, and pTNM stage. Model performance was evaluated by the concordance index (c-index). Risk group stratification was proposed for the nomograms. Results The nomograms are able to pred...read more
Citations
More filters
Journal ArticleDOI
Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
TL;DR: This book aims to provide a history of Radiotherapy and Oncology in Europe and investigates the role of radiotherapy in the development of central nervous system disorders.
Journal ArticleDOI
ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making
H.-J. Schmoll,E. Van Cutsem,Alexander Stein,Vincenzo Valentini,Bengt Glimelius,Bengt Glimelius,Karin Haustermans,Bernard Nordlinger,C.J.H. van de Velde,Judith Balmaña,Jaroslaw Regula,Iris D. Nagtegaal,Regina G. H. Beets-Tan,D Arnold,Fortunato Ciardiello,Paulo M. Hoff,David J. Kerr,C.-H. Köhne,Roberto Labianca,Timothy J. Price,Werner Scheithauer,Alberto Sobrero,Josep Tabernero,Dan Aderka,S Barroso,György Bodoky,J.-Y. Douillard,H El Ghazaly,Jorge Gallardo,August Garin,Rob Glynne-Jones,Karin Jordan,A Meshcheryakov,D Papamichail,Per Pfeiffer,Ioannis Souglakos,Serdar Turhal,Andrés Cervantes +37 more
TL;DR: This ESMO guideline is recommended to be used as the basis for treatment and management decisions, delivering a clear proposal for diagnostic and treatment measures in each stage of rectal and colon cancer and the individual clinical situations.
Journal ArticleDOI
Development and Validation of a Nomogram for Predicting Survival in Patients With Resected Non–Small-Cell Lung Cancer
Wenhua Liang,Li Zhang,Gening Jiang,Qun Wang,Lunxu Liu,Deruo Liu,Zheng Wang,Zhihua Zhu,Qiuhua Deng,Xinguo Xiong,Wenlong Shao,Xiaoshun Shi,Jianxing He +12 more
TL;DR: A novel nomogram is established and validated that can provide individual prediction of OS for patients with resected NSCLC and may help clinicians in decision making and design of clinical studies.
Book ChapterDOI
Colon and Rectum
Carolyn C. Compton,David R. Byrd,Julio Garcia-Aguilar,Scott H. Kurtzman,Alexander B. Olawaiye,Mary Kay Washington +5 more
TL;DR: In the sixth edition, Stage II was subdivided into IIA and IIB on the basis of whether the primary tumor was T3N0 or T4N0, respectively, and Stage III was subdivides into IIIA, IIIB, or IIIC (any TN2M0).
Journal ArticleDOI
EURECCA colorectal: Multidisciplinary management: European consensus conference colon & rectum
Cornelis J.H. van de Velde,Petra G. Boelens,Josep M. Borràs,Jan Willem Coebergh,Andrés Cervantes,Lennart Blomqvist,Regina G. H. Beets-Tan,Colette B.M. van den Broek,Gina Brown,Eric Van Cutsem,Eloy Espin,Karin Haustermans,Bengt Glimelius,Lene Hjerrild Iversen,J. Han van Krieken,Corrie A.M. Marijnen,Geoffrey Henning,Jola Gore-Booth,E. Meldolesi,Pawel Mroczkowski,Iris D. Nagtegaal,Peter Naredi,H. Ortiz,Lars Påhlman,Philip Quirke,Claus Rödel,Arnaud Roth,Harm J. T. Rutten,Hans J. Schmoll,J. J. Smith,Pieter J. Tanis,Claire Taylor,A. Wibe,Theo Wiggers,Maria Antonietta Gambacorta,Cynthia Aristei,Vincenzo Valentini +36 more
TL;DR: The first multidisciplinary consensus conference about cancer of the colon and rectum was held in December 2012 as mentioned in this paper, where the expert panel consisted of representatives of European scientific organisations involved in cancer care of patients with colon and Rectal cancer and representatives of national colorectal registries.
References
More filters
Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
BookDOI
Regression modeling strategies : with applications to linear models, logistic regression, and survival analysis
TL;DR: In this article, the authors present a case study in least squares fitting and interpretation of a linear model, where they use nonparametric transformations of X and Y to fit a linear regression model.
Journal ArticleDOI
Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer
Rolf Sauer,Heinz Becker,Werner Hohenberger,Claus Rödel,Christian Wittekind,Rainer Fietkau,Peter Martus,Jörg Tschmelitsch,Eva Hager,Clemens F. Hess,Torsten Liersch,Heinz Schmidberger,Rudolf Raab +12 more
TL;DR: Preoperative chemoradiotherapy, as compared with postoperative cheMoradi therapy, improved local control and was associated with reduced toxicity but did not improve overall survival.
Journal ArticleDOI
Chemotherapy with preoperative radiotherapy in rectal cancer
Jean-François Bosset,Laurence Collette,Gilles Calais,Laurent Mineur,Philippe Maingon,L. Radosevic-Jelic,Alain Daban,Etienne Bardet,Alexander Beny,Jean-Claude Ollier +9 more
TL;DR: In patients with rectal cancer who receive preoperative radiotherapy, adding fluorouracil-based chemotherapy preoperatively or postoperatively has no significant effect on survival.
Journal ArticleDOI
How To Build and Interpret a Nomogram for Cancer Prognosis
TL;DR: This guide provides a nonstatistical audience with a methodological approach for building, interpreting, and using nomograms to estimate cancer prognosis or other health outcomes.
Related Papers (5)
Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data
Monique Maas,Patty J. Nelemans,Vincenzo Valentini,Prajnan Das,Claus Rödel,Li Jen Kuo,Felipe A. Calvo,Julio Garcia-Aguilar,Rob Glynne-Jones,Karin Haustermans,Mohammed Mohiuddin,Salvatore Pucciarelli,William Small,Javier Suárez,George Theodoropoulos,Sebastiano Biondo,Sebastiano Biondo,Regina G. H. Beets-Tan,Geerard L. Beets +18 more