Journal ArticleDOI
Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P−R from a Marine-Derived Fungus, Aspergillus sp.
Reads0
Chats0
TLDR
Notoamide O possesses a novel hemiacetal/hemiaminal ether functionality hitherto unknown among this family of prenylated indole alkaloids in the biogenetic pathway.Abstract:
Notoamides O−R were isolated from a marine-derived Aspergillus sp. Notoamide O possesses a novel hemiacetal/hemiaminal ether functionality hitherto unknown among this family of prenylated indole alkaloids. The structure represents an unusual branch point for the oxidative modification of other members in the family of prenylated indole alkaloids in the biogenetic pathway.read more
Citations
More filters
Journal ArticleDOI
Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
2,5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products.
Journal ArticleDOI
Secondary metabolites of fungi from marine habitats.
TL;DR: An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties.
Journal ArticleDOI
Review: Marine natural products
TL;DR: This review covers the literature published in 2010 for marine natural products, with 895 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Marine Indole Alkaloids
Natalie Netz,Till Opatz +1 more
TL;DR: Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors.
References
More filters
Journal ArticleDOI
Chemistry and Biology of Mycotoxins and Related Fungal Metabolites
Journal ArticleDOI
Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis
TL;DR: Prenylated indole alkaloids are hybrid natural products derived from prenyl diphosphates and tryptophan or its precursors and widely distributed in filamentous fungi, especially in the genera Penicillium and Aspergillus of ascomycota.
Journal ArticleDOI
Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal ()-Stephacidin A and (+)-Notoamide B from Aspergillus versicolor NRRL 35600**
Thomas J. Greshock,Alan W. Grubbs,Ping Jiao,Donald T. Wicklow,Donald T. Wicklow,James B. Gloer,Robert M. Williams +6 more
TL;DR: The isolation, structure elucidation, and confirmatory biomimetic total synthesis of the first member of the paraherquamide-stephacidin family to possess the rare anti-relative stereochemistry within the bicyclo-diazaoctane ring system are described.
Journal ArticleDOI
Notoamides A–D: Prenylated Indole Alkaloids Isolated from a Marine‐Derived Fungus, Aspergillus sp.
Hikaru Kato,Takushi Yoshida,Takanori Tokue,Yuka Nojiri,Hiroshi Hirota,Tomihisa Ohta,Robert M. Williams,Robert M. Williams,Sachiko Tsukamoto +8 more
TL;DR: Six new prenylated indole alkaloids, named notoamides F−K (8−13), were isolated from a marine-derived Aspergillus sp.
Journal ArticleDOI
Stephacidin A and B: two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells.
Jingfang Qian-Cutrone,Stella Huang,Yue-Zhong Shu,Dolatrai M. Vyas,Craig Fairchild,Ana T. Menendez,Kimberly D. Krampitz,Richard A. Dalterio,Steven E. Klohr,Qi Gao +9 more
TL;DR: Both alkaloids exhibit in vitro cytotoxicity against a number of human tumor cell lines; however, stephacidin B demonstrated more potent and selective antitumor activities, especially against prostate testeosterone-dependent LNCaP cells with IC50 value of 60 nM.