Journal ArticleDOI
Novel and efficient MR active aqueous colloidal Fe3O4 nanoassemblies
K.C. Barick,Mohammed Aslam,Yen Po Lin,Dhirendra Bahadur,Pottumarthi V. Prasad,Vinayak P. Dravid +5 more
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TLDR
In this paper, a new class of magnetic resonance (MR) active aqueous Fe3O4 magnetic nanoparticle nanoassemblies (Fe 3O4 MNNA) of ∼40 nm size comprising ∼6 nm particles are presented.Abstract:
This work demonstrates a new class of magnetic resonance (MR) active aqueous Fe3O4 magnetic nanoparticle nanoassemblies (Fe3O4 MNNA) of ∼40 nm size comprising ∼6 nm particles. They exhibit enhancement in T2 MR contrast as compared to 6 nm isolated counterparts (Fe3O4MNP) and commercial contrast agent, ferumoxytol. This significant improvement in the T2 MR signal arises from the synergistic magnetism of multiple Fe3O4nanoparticles assembled in Fe3O4 MNNA. These nanoassemblies also show better colloidal stability, higher magnetization, good specific absorption rate (under external AC magnetic field) and cytocompatibility with cells. Further, the functional groups (–NH2) present on the surface of Fe3O4 particles can be accessible for routine conjugation of biomolecules through well-developed bioconjugation chemistry. Specifically, a new MR active colloidal amine-functionalized Fe3O4 nanoassembly with enhanced T2 contrast properties has been fabricated, which can also be used as an effective heating source for hyperthermia treatment of cancer.read more
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Effects of Nanoparticle Size on Cellular Uptake and Liver MRI with Polyvinylpyrrolidone-Coated Iron Oxide Nanoparticles
Jing Huang,Lihong Bu,Lihong Bu,Jin Xie,Kai Chen,Zhen Cheng,Xingguo Li,Xiaoyuan Chen,Xiaoyuan Chen +8 more
TL;DR: It was found that cellular uptake changed with both size and surface physiochemical properties, and that PVP-IO-37 with a core size of 37 nm and hydrodynamic particle size of 100 nm exhibited higher cellular uptake rate and greater distribution than other PVPs and Feridex.
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Surface engineered magnetic nanoparticles for removal of toxic metal ions and bacterial pathogens.
TL;DR: These surface engineered magnetic nanoparticles show superparamagnetic behavior at room temperature with strong field dependent magnetic responsivity and can be used as highly efficient separable and reusable materials for removal of toxic metal ions.
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Role of functionalization: strategies to explore potential nano-bio applications of magnetic nanoparticles
TL;DR: The current review focuses on the theoretical background regarding thefunctionalization of magnetic nanoparticles for nano-bio applications and covers all the important aspects regarding the functionalization of magnet nanoparticles.
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Iron oxide nanorods as high-performance magnetic resonance imaging contrast agents.
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References
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Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications
Sophie Laurent,Delphine Forge,Marc Port,Alain Roch,Caroline Robic,Luce Vander Elst,Robert N. Muller +6 more
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Magnetic nanoparticle design for medical diagnosis and therapy
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