Journal ArticleDOI
Novel Thermoreversible Gelation of Biodegradable PLGA-block-PEO-block-PLGA Triblock Copolymers in Aqueous Solution
TLDR
In this article, the BAB-type triblock copolymers composed of a central poly(ethyelene oxide) (PEO, M nPEO = 1000) block and two poly[(D,L-lactic acid)-co-(glycolic acid)] end blocks with molecular weights between 900 and 1 600 exhibited an intersting phase transition behavior.Abstract:
The BAB-type triblock copolymers composed of a central poly(ethyelene oxide) (PEO, M nPEO = 1000) block and two poly[(D,L-lactic acid)-co-(glycolic acid)] end blocks with molecular weights between 900 and 1 600 exhibited an intersting phase transition behavior. The copolymer aqueous solution can form micelles with PLGA loops in the core and a PEO shell and groups of micelles because of bridging between micelles caused by the PLGA blocks with raising temperature. A possible micellar gelation mechanism was suggested.read more
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Thermosensitive sol-gel reversible hydrogels.
TL;DR: It is timely to summarize the polymeric systems that undergo sol-gel transitions, particularly due to temperature, with emphasis on the underlying transition mechanisms and potential delivery aspects.
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Injectable hydrogels as unique biomedical materials
Lin Yu,Jiandong Ding +1 more
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In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery.
TL;DR: This review focuses on recent development of the preparation and application for drug delivery of the block copolymer hydrogels that respond to temperature, pH or both stimuli, including poly(N-substituted acrylamide)-based blockcopolymers, poloxamers and their derivatives, poly(ethylene glycol)-polyester block copolemers, polyelectrolyte-based blockCopolymers and the polyelectrodynamic-modified thermo-sensitive block
Journal ArticleDOI
Hydrogels in a historical perspective: from simple networks to smart materials.
Sytze J. Buwalda,Kristel W. M. Boere,Pieter J. Dijkstra,Jan Feijen,Tina Vermonden,Wim E. Hennink +5 more
TL;DR: A historical overview of the developments in hydrogel research from simple networks to smart materials is provided to overcome several challenges to overcome for clinical translation.