Journal ArticleDOI
In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery.
TLDR
This review focuses on recent development of the preparation and application for drug delivery of the block copolymer hydrogels that respond to temperature, pH or both stimuli, including poly(N-substituted acrylamide)-based blockcopolymers, poloxamers and their derivatives, poly(ethylene glycol)-polyester block copolemers, polyelectrolyte-based blockCopolymers and the polyelectrodynamic-modified thermo-sensitive blockAbout:
This article is published in Journal of Controlled Release.The article was published on 2008-05-08. It has received 792 citations till now. The article focuses on the topics: Self-healing hydrogels & Drug carrier.read more
Citations
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Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications
TL;DR: The review includes the novel naturally based hydrogels with high potential for biomedical applications developed in the past five years which integrate the excellent biocompatibility of natural polymers/synthetic polypeptides with structural controllability via chemical modification.
Journal ArticleDOI
Thermoresponsive hydrogels in biomedical applications.
Leda Klouda,Antonios G. Mikos +1 more
TL;DR: The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change and focuses mainly on hydrogels based on natural polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers.
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Biodegradable synthetic polymers: Preparation, functionalization and biomedical application
TL;DR: This review presents a comprehensive introduction to various types of synthetic biodegradable polymers with reactive groups and bioactive groups, and further describes their structure, preparation procedures and properties.
Journal ArticleDOI
Hydrogels for protein delivery.
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Stimulus-responsive hydrogels: Theory, modern advances, and applications
TL;DR: This extensive review identifies and discusses the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels.
References
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Journal ArticleDOI
Hydrogels for biomedical applications.
TL;DR: The composition and synthesis of hydrogels, the character of their absorbed water, and permeation of solutes within their swollen matrices are reviewed to identify the most important properties relevant to their biomedical applications.
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Environment-sensitive hydrogels for drug delivery
Yong Qiu,Kinam Park +1 more
TL;DR: Development of environmentally sensitive hydrogels with a wide array of desirable properties can be made is a formidable challenge, however, if the achievements of the past can be extrapolated into the future, it is highly likely that responsive hydrogelWith such properties can been made.
Journal ArticleDOI
Thermo- and pH-responsive polymers in drug delivery.
TL;DR: The majority of examples, discussed in this paper, deal with pH-responsive drug delivery system, and Thermo-responsive polymer is also covered to a large extent, as well as double-responsive system.
Journal ArticleDOI
Stimuli-reponsive polymers and their bioconjugates
Eun Seok Gil,Samuel M. Hudson +1 more
TL;DR: In this article, the authors focused on temperature and pH responsive polymer systems and additionally the other stimuli-based responsive polymers will be assessed, which is more helpful to design new approaches because the basic concepts and mechanisms are systematically connected.