Journal ArticleDOI
One-pot synthesis of amine-substituted aryl sulfides and benzo[b]thiophene derivatives.
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TLDR
The cross-coupling reactions of nitro- and aldehyde-substituted aryl halides with benzyl thiols under the same reaction conditions were demonstrated to afford benzothiazole and phenylbenzo[b]thiophene derivatives.About:
This article is published in Organic Letters.The article was published on 2010-04-26. It has received 80 citations till now. The article focuses on the topics: Aryl & Benzothiazole.read more
Citations
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Journal ArticleDOI
Recent Developments in the Reduction of Aromatic and Aliphatic Nitro Compounds to Amines
TL;DR: The review will offer an overview of the different possible methodologies available for the nitro group reduction, with special attention on the most efficient and selective nitro reduction methods for chiral amino groups.
Journal ArticleDOI
Copper-mediated C-H activation/C-S cross-coupling of heterocycles with thiols
Sadananda Ranjit,Richmond Lee,Dodi Heryadi,Chao Shen,Ji'en Wu,Pengfei Zhang,Kuo-Wei Huang,Xiaogang Liu,Xiaogang Liu +8 more
TL;DR: Computational studies suggest a stepwise reaction mechanism based on a hydrogen atom abstraction pathway, which is more energetically feasible than many other possible pathways including β-hydride elimination, single electron transfer, hydrogen atom transfer, oxidative addition/reductive elimination, and σ-bond metathesis.
Journal ArticleDOI
Synthesis of vinyl sulfides by copper-catalyzed decarboxylative C-S cross-coupling.
TL;DR: A novel method for the synthesis of vinyl sulfides by the decarboxylative cross-coupling of arylpropiolic acids with thiols using copper(I) salts as catalysts has been developed.
Journal ArticleDOI
Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions
Vaibhav P. Mehta,Benudhar Punji +1 more
TL;DR: In this paper, the authors highlight the recent progress in the field of transition-metal-free direct C-C and C-heteroatom bond forming reactions via the use of a strong base and (or) an oxidant.
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Dimethyl Sulfoxide/Potassium Hydroxide: A Superbase for the Transition Metal‐Free Preparation of Cross‐Coupling Products
Yu Yuan,Isabelle Thome,Seok Hwan Kim,Seok Hwan Kim,Duanteng Chen,Astrid Beyer,Julien Bonnamour,Erik Zuidema,Sukbok Chang,Carsten Bolm +9 more
TL;DR: Potassium hydroxide (KOH) in dimethyl sulfoxide (DMSO) forms a superbasic medium that allows one to access cross-coupling products from reactions between aryl halides with various sulfur-, oxygen- and nitrogen-based nucleophiles under transition metal-free conditions as discussed by the authors.
References
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Journal ArticleDOI
Reduction of Nitro Aromatic Compounds by Zero-Valent Iron Metal
Abinash Agrawal,Paul G. Tratnyek +1 more
TL;DR: The properties of iron metal that make it useful in remediation of chlorinated solvents may also lead to reduction of other groundwater contaminants such as nitro aromatic compounds (NACs) as mentioned in this paper.
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A general and long-lived catalyst for the palladium-catalyzed coupling of aryl halides with thiols.
TL;DR: A general catalytic system for the coupling of aryl halides and sulfonates with thiols based on the use of the CyPF-t-Bu ligand and the synthesis of a diarylsulfide from two bromoarenes was accomplished using a hydrogen sulfide surrogate.
Journal ArticleDOI
Cobalt-Catalyzed Aryl−Sulfur Bond Formation
TL;DR: A new cobalt-catalyzed coupling of aryl halides with thiophenols and alkanethiols is reported, which represents an interesting addition to previously known methods to synthesize thioethers.
Journal ArticleDOI
Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs.
TL;DR: A series of water-soluble L-lysyl- and L-alanyl-amide prodrugs of the lipophilic antitumor 2-(4-aminophenyl)benzothiazoles has been synthesized to address formulation and bioavailability issues related to the desired parenteral administration of the chosen clinical candidate.
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