Journal ArticleDOI
One-Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy
Sainan Liu,Sainan Liu,Chunling Hu,Chunling Hu,Ying Liu,Xueyan Zhao,Maolin Pang,Maolin Pang,Jun Lin,Jun Lin +9 more
TLDR
In this work, doxorubicin (DOX) was successfully in situ loaded into a COF by a one-pot method for the first time and the resultant DOX@COF platform exhibited high drug-loading capacity (32.1 wt %) and pH-responsive release property.Abstract:
Covalent organic frameworks (COFs) have attracted great attention across diverse research fields. However, only a few reports about the biomedical application of COFs are found in the literature. Attributed to the highly porous and tunable structure, as well as good thermal stability, COFs show great potential as drug carriers for chemotherapy. In this work, doxorubicin (DOX) was successfully in situ loaded into a COF by a one-pot method for the first time. The resultant DOX@COF platform exhibited high drug-loading capacity (32.1 wt %) and pH-responsive release property. In vitro and in vivo experiments demonstrated its good biocompatibility and enhanced antitumor efficacy.read more
Citations
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Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy
TL;DR: A nanoscale COF prepared via a facile synthetic approach under ambient conditions and a dual-modal PDT/PTT therapeutic nanoagent, VONc@COF-Por, is successfully fabricated by stepwise BDF and guest encapsulation processes to obtain multifunctional nanomedicines for PDT/ PTT combination therapy.
Journal ArticleDOI
Nature-Inspired Construction of MOF@COF Nanozyme with Active Sites in Tailored Microenvironment and Pseudopodia-Like Surface for Enhanced Bacterial Inhibition
Lu Zhang,Zhengwei Liu,Qingqing Deng,Qingqing Deng,Yanjuan Sang,Yanjuan Sang,Kai Dong,Jinsong Ren,Jinsong Ren,Xiaogang Qu,Xiaogang Qu +10 more
TL;DR: A MOF@COF nanozyme has been designed as a high-efficiency peroxidase mimic, with the metallic nodes of MOFs as active centres, the hierarchical nanocavities produced by the growth of covalent organic frameworks (COFs) as binding pockets to form tailored pore microenvironment around active sites for enriching and activating substrate molecules, to perform enhanced bacterial inhibition.
Journal ArticleDOI
BODIPY-Decorated Nanoscale Covalent Organic Frameworks for Photodynamic Therapy.
Qun Guan,Dan-Dan Fu,Yan-An Li,Xiang-Mei Kong,Zhi-Yuan Wei,Wen-Yan Li,Shaojun Zhang,Yu-Bin Dong +7 more
TL;DR: BODIPY has been successfully nanocrystallized via the NCOF platform, and can be used for photodynamic therapy (PDT) to treat tumors and might open up new avenues for the fabrication of additional COF-based platforms for biomedical treatment.
Journal ArticleDOI
Covalent Organic Frameworks (COFs) for Cancer Therapeutics
TL;DR: This contribution provides an overview of recent developments of COF-based medicines in cancer therapeutics, including drug delivery, photodynamic therapy (PDT), photothermal therapy (PTT), and combined therapy.
Journal ArticleDOI
Evolution of Nanocarrier Drug-Delivery Systems and Recent Advancements in Covalent Organic Framework–Drug Systems
TL;DR: This research presents a novel approach to nanomedicine that addresses the challenge of integrating nanofiltration into the delivery mechanism of drugs to overcome the limitations of conventional carriers.
References
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Journal ArticleDOI
Porous, Crystalline, Covalent Organic Frameworks
Adrien P. Côté,Annabelle I. Benin,Nathan W. Ockwig,Michael O'Keeffe,Adam J. Matzger,Omar M. Yaghi +5 more
TL;DR: Covalent organic frameworks (COFs) have been designed and successfully synthesized by condensation reactions of phenyl diboronic acid and hexahydroxytriphenylene to form rigid porous architectures with pore sizes ranging from 7 to 27 angstroms.
Journal ArticleDOI
Drug Delivery Systems: Entering the Mainstream
TL;DR: There is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
Journal ArticleDOI
Covalent organic frameworks (COFs): from design to applications
San-Yuan Ding,Wei Wang +1 more
TL;DR: This critical review describes the state-of-the-art development in the design, synthesis, characterisation, and application of the crystalline porous COF materials.
Journal ArticleDOI
Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
TL;DR: The fundamental concepts of enhanced permeability and retention effect (EPR) are revisited and the mechanisms proposed to enhance preferential "retention" in the tumor, whether using active targeting of nanoparticles, binding of drugs to their tumoral targets or the presence of tumor associated macrophages are explored.