Journal ArticleDOI
One-pot synthesis of indolizine via 1,3-dipolar cycloaddition using a sub-equivalent amount of K2Cr2O7 as an efficient oxidant under base free conditions
TLDR
In this paper, a one-pot method for synthesizing multi-substituted indolizines from α-halo-carbonyl compounds, pyridines and electron deficient alkenes was developed.Abstract:
A one-pot method for synthesizing multi-substituted indolizines from α-halo-carbonyl compounds, pyridines and electron deficient alkenes was developed. A sub-equivalent amount of potassium dichromate was used as an oxidant under base free conditions. The transformation developed should be of economic efficiency.read more
Citations
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Journal ArticleDOI
In Situ Generation of Quinolinium Ylides from Diazo Compounds: Copper-Catalyzed Synthesis of Indolizine.
TL;DR: The Cu-catalyzed three-component reaction between quinolines, diazo compounds, and alkenes has been established for direct construction of indolizine derivatives via quinolinium ylides.
Journal ArticleDOI
Synthesis of indolizines through aldehyde–amine–alkyne couplings using metal-organic framework Cu-MOF-74 as an efficient heterogeneous catalyst
TL;DR: In this article, a crystalline copper-based metal-organic framework was synthesized, and was characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), TEM, thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), atomic absorption spectrophotometry (AAS), and nitrogen physisorption measurements.
Journal ArticleDOI
Diversified Transformations of Tetrahydroindolizines to Construct Chiral 3-Arylindolizines and Dicarbofunctionalized 1,5-Diketones.
Dong Zhang,Zhishan Su,Qianwen He,Zhikun Wu,Yuqiao Zhou,Chenjing Pan,Xiaohua Liu,Xiaoming Feng +7 more
TL;DR: A breakthrough is reported via an initial diastereo- and enantioselective [3+2] cycloaddition between pyridinium ylides and enones, following diversified sequential transformations of tetrahydroindolizines in successions.
Journal ArticleDOI
Copper-mediated oxidative [3 + 2]-annulation of nitroalkenes and pyridinium ylides: general access to functionalized indolizines and efficient synthesis of 1-fluoroindolizines.
Vladimir A. Motornov,Andrey A. Tabolin,Yulia V. Nelyubina,Valentine G. Nenajdenko,Sema L. Ioffe +4 more
TL;DR: First synthesis of monofluorinated [3,2,2]cyclazines was demonstrated via oxidative annulation of 3-unsubstituted fluoroindolizines with diethyl acetylene dicarboxylate through application of the copper(ii) acetate-2,6-lutidine system.
Journal ArticleDOI
Application of primary halogenated hydrocarbons for the synthesis of 3-aryl and 3-alkyl indolizines.
TL;DR: A transition-metal-free synthetic route to 3-aryl and 3-alkyl indolizines from electron-deficient alkenes, pyridines and primary halogenated hydrocarbons has been reported for the first time using a tandem reaction.
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
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Recent Developments of Transition-State Analogue Glycosidase Inhibitors of Non-Natural Product Origin
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Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds.
TL;DR: Although only a few of the over 800 amphibian skin alkaloids have been detected in arthropods, putative arthropod sources for the batrachotoxins and coccinelline-like tricyclics (beetles), the pumiliotoxin (ants, mites), the decahydroquinolines, izidine, pyrrolidines, and piperidines (ants), and the spirop
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5-Hydroxytryptamine (5-HT3) Receptor Antagonists. 1. Indazole and Indolizine-3-carboxylic Acid Derivatives
Jose Bermudez,Charles S. Fake,Graham F. Joiner,Karen A. Joiner,Frank D. King,Wesley D. Miner,Gareth J. Sanger +6 more
TL;DR: 6g (BRL 43694) was found to be both potent and selective and has been shown to be a very effective antiemetic agent against cytotoxic drug induced emesis both in the ferret and in man.
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Novel heterocyclic analogues of the new potent class of calcium entry blockers: 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
Jean Gubin,Hendrik de Vogelaer,Henri Inion,Christian Houben,Jean Lucchetti,Jean Mahaux,Gilbert Rosseels,Maurits A. Peiren,M. Clinet +8 more
TL;DR: Several heterocyclic analogues of the potent 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines were synthesized and evaluated for their antagonistic calcium activities and the indole nucleus appeared to be extremely favorable to support the calcium antagonistic activity.