Orexin A excites the rat olivary pretectal nucleus via OX2 receptor in a daily manner.
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TLDR
In this paper, the olivary pretectal nucleus (OPN) was found to be a retinorecipient structure primarily involved in the pupillary light reflex.About:
This article is published in Brain Research.The article was published on 2021-05-13 and is currently open access. It has received 4 citations till now. The article focuses on the topics: Orexin-A & Orexin.read more
Citations
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Journal ArticleDOI
Daily coordination of orexinergic gating in the rat superior colliculus—Implications for intrinsic clock activities in the visual system
Lukasz Chrobok,Jagoda Stanislawa Jeczmien-Lazur,Monika Bubka,Kamil Pradel,Aleksandra Klekocinska,Jasmin Daniela Klich,Amalia Ridla Rahim,Jihwan Myung,Mariusz Kepczynski,Marian H. Lewandowski +9 more
TL;DR: In this paper, a combination of electrophysiological, immunohistochemical, and molecular approaches across 24 hours was used to investigate the daily coordination between the orexin system and the superior colliculus (SC).
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From Fast Oscillations to Circadian Rhythms: Coupling at Multiscale Frequency Bands in the Rodent Subcortical Visual System
TL;DR: The subcortical visual system (SVS) is a unique collection of brain structures localised in the thalamus, hypothalamus and midbrain this article, which receives ambient light inputs from retinal ganglion cells and integrates this signal with internal homeostatic demands to influence physiology.
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Control and coding of pupil size by hypothalamic orexin neurons
TL;DR: In this paper , cell-specific stimulation, deletion and in vivo recordings revealed strong correlative and causal links between pupil dilation and orexin cell activity, indicating that they specialize in rapid, multiplexed communication of momentary arousal and reward states.
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Metabolic cues impact non‐oscillatory intergeniculate leaflet and ventral lateral geniculate nucleus: standard versus high‐fat diet comparative study
TL;DR: In this article , the effect of metabolically relevant peptides on the spontaneous activity of IGL/VLG neurons was investigated using ex vivo and in vivo electrophysiological recordings as well as in situ hybridisation.
References
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Journal ArticleDOI
The influence of orexins on the firing rate and pattern of rat intergeniculate leaflet neurons--electrophysiological and immunohistological studies.
TL;DR: The presented findings are the first showing the direct influence of orexins on the IGL activity, mostly through activation of OX2R.
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Orphan G protein-coupled receptors and obesity
TL;DR: Four deorphanized GPCR systems are discussed, the ghrelin, orexins/hypocretins, melanin-concentrating hormone (MCH) and neuropeptide B/neuropeptides W (NPB/NPW) systems, and knowledge of their role in the regulation of energy balance and of their potential use in therapies directed at feeding disorders is reviewed.
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Orexins/hypocretins modulate the activity of NPY-positive and -negative neurons in the rat intergeniculate leaflet via OX1 and OX2 receptors
TL;DR: This study evaluated the effects of orexins on identified IGL neurons revealing that 58% of the recorded neurons were sensitive to OXA and OXB administration, and observed an increase of GABA release onto the investigated IGL neuron after OxA application, consistent with a presynaptic localization of the orexin receptors.
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The retinal ganglion cells that drive the pupilloconstrictor response in rats
Michael J. Young,Raymond D. Lund +1 more
TL;DR: It is well established that the pupillary light reflex in rats is mediated by a direct retinal projection to the olivary pretectal nucleus (OPN), and microinjections of Fluoro-Gold into the OPN are used to retrogradely label RGCs projecting to this region.
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Daily Fluctuation of Orexin Neuron Activity and Wiring: The Challenge of "Chronoconnectivity".
TL;DR: It is highlighted that synaptic plasticity in the wiring of orexin neurons also occurs in unperturbed conditions and could account for diurnal variations of oRexin neuron activity, which opens questions on the underlying circadian and homeostatic regulation and on the involved players at synaptic level.