Organ-level quorum sensing directs regeneration in hair stem cell populations
Chih Chiang Chen,Lei Wang,Maksim V. Plikus,Ting-Xin Jiang,Philip J. Murray,Raul Ramos,Christian F. Guerrero-Juarez,Michael W. Hughes,Oscar K. Lee,Songtao Shi,Randall B. Widelitz,Arthur D. Lander,Cheng-Ming Chuong,Cheng-Ming Chuong,Cheng-Ming Chuong +14 more
TLDR
By coupling immune response with regeneration, this mechanism allows skin to respond predictively to distress, disregarding mild injury, while meeting stronger injury with full-scale cooperative activation of stem cells.About:
This article is published in Cell.The article was published on 2015-04-09 and is currently open access. It has received 201 citations till now. The article focuses on the topics: Regeneration (biology).read more
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Macrophages in Tissue Repair, Regeneration, and Fibrosis
Thomas A. Wynn,Kevin M. Vannella +1 more
TL;DR: This review discusses the mechanisms that instruct macrophages to adopt pro-inflammatory, pro-wound-healing,pro-fibrotic, anti- inflammatory, anti -fib rotic, Pro-resolving, and tissue-regenerating phenotypes after injury, and highlights how some of these mechanisms and macrophage activation states could be exploited therapeutically.
Journal ArticleDOI
Quorum sensing signal–response systems in Gram-negative bacteria
Kai Papenfort,Bonnie L. Bassler +1 more
TL;DR: This Review examines how features of quorum sensing signal–response systems combine to control collective behaviours in Gram-negative bacteria and the implications for host–microbial associations and antibacterial therapy.
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The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
Birgit Ritschka,Mekayla Storer,Alba Mas,Florian Heinzmann,Mari Carmen Ortells,Jennifer P. Morton,Owen J. Sansom,Lars Zender,Lars Zender,William M. Keyes,William M. Keyes +10 more
TL;DR: A primary and beneficial role is uncovered for the senescence-associated secretory phenotype in promoting cell plasticity and tissue regeneration and the concept that transient therapeutic delivery of senescent cells could be harnessed to drive tissue regeneration is introduced.
Journal ArticleDOI
Anatomical, Physiological, and Functional Diversity of Adipose Tissue
TL;DR: As the recognition of diverse adipose depot functions increases, novel therapeutic approaches centered on tissue-specific adipocytes are likely to emerge for a range of cancers and regenerative, infectious, and autoimmune disorders.
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Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture
Weng Chuan Peng,Catriona Y. Logan,Matt Fish,Teni Anbarchian,Francis Aguisanda,Adrián Álvarez-Varela,Peng Wu,Yinhua Jin,Junjie Zhu,Bin Li,Markus Grompe,Bruce Wang,Roel Nusse +12 more
TL;DR: In vitro-expanded hepatocytes engrafted, and significantly repopulated, the injured livers of Fah-/- mice, it is shown that TNFα, an injury-induced inflammatory cytokine, promotes the expansion of hepatocytes in 3D culture and enables serial passaging and long-term culture for more than 6 months.
References
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Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
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Quorum Sensing in Bacteria
TL;DR: The evolution of quorum sensing systems in bacteria could, therefore, have been one of the early steps in the development of multicellularity.
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Controls of hair follicle cycling.
Kurt S. Stenn,Ralf Paus +1 more
TL;DR: This review has used Chase as the model and tried to put the adult hair follicle growth cycle in perspective, and hopes that this work will serve as an introduction to basic biologists who are looking for a defined biological system that illustrates many of the challenges of modern biology.
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A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages.
Sven Müller-Röver,Bori Handjiski,Carina van der Veen,Stefan B. Eichmüller,Kerstin Foitzik,Ian A. McKay,Kurt S. Stenn,Ralf Paus +7 more
TL;DR: This guide should become a useful tool when screening new mouse mutants or mice treated with pharmaceuticals for discrete morphologic abnormalities of hair follicle cycling in a highly reproducible, easily applicable, and quantifiable manner.
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Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
Sarah Schwitalla,Alexander A. Fingerle,Patrizia Cammareri,Tim Nebelsiek,Serkan Ismail Göktuna,Paul Ziegler,Özge Canli,Jarom Heijmans,David J. Huels,Guenievre Moreaux,Rudolf A. Rupec,Markus Gerhard,Roland M. Schmid,Nick Barker,Hans Clevers,Roland Lang,Jens Neumann,Thomas Kirchner,Makoto Mark Taketo,Gijs R. van den Brink,Owen J. Sansom,Melek C. Arkan,Florian R. Greten +22 more
TL;DR: This work demonstrates that NF-κB modulates Wnt signaling and shows that IEC-specific ablation of RelA/p65 retards crypt stem cell expansion and highlights the importance of inflammatory signaling for dedifferentiation and generation of tumor-initiating cells in vivo.