Organization and function of membrane contact sites.
Sebastian Carsten Johannes Helle,Gil Kanfer,Katja Kolar,Alexander Lang,Agnès H. Michel,Benoît Kornmann +5 more
Reads0
Chats0
TLDR
This review will focus on the common organizing principles underlying the many MCSs found between the ER and virtually all compartments of the cell, and on how the ER establishes a network of M CSs for the trafficking of vital metabolites and information.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-11-01 and is currently open access. It has received 388 citations till now. The article focuses on the topics: Membrane contact site & Endomembrane system.read more
Citations
More filters
Journal ArticleDOI
A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP
Bruno Mesmin,Joëlle Bigay,Joachim Moser von Filseck,Sandra Lacas-Gervais,Guillaume Drin,Bruno Antonny +5 more
TL;DR: OSBP-mediated back transfer of PI(4)P might coordinate the transfer of other lipid species at the ER-Golgi interface, suggesting the ability to both tether organelles and transport lipids between them.
Journal ArticleDOI
Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling.
TL;DR: This work has shown that loss of nutrients/energy leads to the loss of cellular homeostasis and disruption of Ca(2+) signaling in both the reticular network and cytoplasmic compartments, and this leads to activation of ER stress coping responses, such as the unfolded protein response (UPR), and mobilization of pathways to regain ERHomeostasis.
Journal ArticleDOI
Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics
TL;DR: Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelle have also begun to be characterized.
Journal ArticleDOI
ER Contact Sites Define the Position and Timing of Endosome Fission
TL;DR: It is demonstrated that the site of constriction and fission for early and late endosomes is spatially and temporally linked to contact sites with the ER, and altering ER structure and dynamics reduces the efficiency of endosome fission.
Journal ArticleDOI
There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases
Sebastien Paillusson,Radu Stoica,Patricia Gomez-Suaga,Dawn H. W. Lau,Sarah M. Mueller,Tanya Miller,Christopher C.J. Miller +6 more
TL;DR: Several recent studies have shown that disturbances to ER–mitochondria contacts occur in neurodegenerative diseases, and this work reviews these findings.
References
More filters
Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
Membrane lipids: where they are and how they behave.
TL;DR: How do cells apply anabolic and catabolic enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functions of their individual membranes?
Journal ArticleDOI
Genomic expression programs in the response of yeast cells to environmental changes.
Audrey P. Gasch,Paul T. Spellman,Camilla M. Kao,Orna Carmel-Harel,Michael B. Eisen,Gisela Storz,David Botstein,Patrick O. Brown +7 more
TL;DR: Analysis of genomic expression patterns in the yeast Saccharomyces cerevisiae implicated the transcription factors Yap1p, as well as Msn2p and Msn4p, in mediating specific features of the transcriptional response, while the identification of novel sequence elements provided clues to novel regulators.
Journal ArticleDOI
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.
Journal ArticleDOI
Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses
Rosario Rizzuto,Paolo Pinton,Paolo Pinton,Walter A. Carrington,Walter A. Carrington,Frederic S. Fay,Frederic S. Fay,Kevin E. Fogarty,Kevin E. Fogarty,Lawrence M. Lifshitz,Lawrence M. Lifshitz,Richard A. Tuft,Richard A. Tuft,Tullio Pozzan,Tullio Pozzan +14 more
TL;DR: The spatial relation between mitochondria and endoplasmic reticulum in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins to emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling.