Journal ArticleDOI
Organocatalytic aryl-aryl bond formation: An atroposelective [3,3]-rearrangement approach to BINAM derivatives
TLDR
Density functional calculations reveal that, in the transition state for C-C bond formation, the phosphoric acid proton of the catalyst is fully transferred to one of the N-atoms of the substrate, and the resulting phosphate acts as a chiral counterion.Abstract:
Herein we disclose an organocatalytic aryl–aryl bond-forming process for the regio- and atroposelective synthesis of 2,2′-diamino-1,1′-binaphthalenes (BINAMs). In the presence of catalytic amounts of axially chiral phosphoric acids, achiral N,N′-binaphthyl hydrazines undergo a facile [3,3]-sigmatropic rearrangement to afford enantiomerically enriched BINAM derivatives in good to excellent yield. This transformation represents the first example of a metal-free, catalytic C(sp2)–C(sp2) bond formation between two aromatic rings with concomitant de novo atroposelective installation of an axis of chirality. Density functional calculations reveal that, in the transition state for C–C bond formation, the phosphoric acid proton of the catalyst is fully transferred to one of the N-atoms of the substrate, and the resulting phosphate acts as a chiral counterion.read more
Citations
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Journal ArticleDOI
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
Journal ArticleDOI
Recent advances and new concepts for the synthesis of axially stereoenriched biaryls
TL;DR: These outstanding steps further unlocked the door to the preparation of previously difficult-to-access precursors of privileged ligands like BINOL, BINAM, QUINAP and many other molecules of interest.
Journal ArticleDOI
Construction of Axially Chiral Compounds via Asymmetric Organocatalysis
Yong-Bin Wang,Bin Tan +1 more
TL;DR: The asymmetric organocatalytic approach to construct axially chiral styrenes through the 1,4-addition of arylalkynals in good chemical yields and enantioselectivities is discovered and the azo group can effectively perform as a directing and activating group for organoc atalytic formal aRYl C-H functionalization via formal nucleophilic aromatic substitution of azobenzene derivatives.
Journal ArticleDOI
Recent development of direct asymmetric functionalization of inert C–H bonds
Chao Zheng,Shu-Li You +1 more
TL;DR: The area of direct asymmetric functionalization of inert C-H bonds has attracted considerable attention in recent years as discussed by the authors, and a lot of strategies have emerged including asymmetric C−H bond insertion by metal carbenoids or analogs, cross dehydrogenative coupling, [1,5]-hydride transfer, C-h bond functionalization involving a transient metal-carbon species and other miscellaneous methods.
Journal ArticleDOI
Recent Advances in Catalytic Asymmetric Construction of Atropisomers.
TL;DR: In this paper, a review summarizes key achievements in stereoselective preparation of biaryl, heterobiaryl, and non-biaryl atropisomers documented between 2015 and 2020.
References
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