Journal ArticleDOI
Overexpression of glut1 and glut3 in stage I nonsmall cell lung carcinoma is Associated with poor survival
TLDR
The aim of this study was to determine the biologic significance of Glut1 and Glut3 overexpression in Stage I NSCLC.Abstract:
BACKGROUND
Increased expression of Glut1 and Glut3 has been reported in many human cancers, including nonsmall cell lung carcinoma (NSCLC). The aim of this study was to determine the biologic significance of Glut1 and Glut3 overexpression in Stage I NSCLC.
METHODS
Using immunohistochemistry and polyclonal anti-Glut1 and anti-Glut3 antibodies, the authors immunostained sections of formalin fixed, paraffin embedded tissues from 289 Stage I NSCLCs. The Kaplan-Meier survival method, the log rank test, and Fisher's exact test were used for statistical analysis.
RESULTS
Of the 289 cases, 49 (17%) were negative for both Glut1 and Glut3, 239 (83%) were Glut1 positive, 61 (21%) were Glut3 positive, 179 (62%) were positive for Glut1 but negative for Glut3, 1 (0.3%) was positive for Glut3 but negative for Glut1, and 60 (21%) were positive for both Glut1 and Glut3. Only 1 of 50 Glut1 negative tumors (2%) was positive for Glut3, whereas 60 of 239 Glut1 positive tumors (25%) were positive for Glut3 (P < 0.0001). Glut1 or Glut3 were detected more often in poorly differentiated and undifferentiated tumors (P <0.0001 and P = 0.0008, respectively). Overexpression of Glut1 and/or Glut3 was associated with poorer survival (P = 0.0133), especially in patients with well-differentiated and moderately differentiated tumors (P = 0.0017).
CONCLUSIONS
In Stage I NSCLC, Glut3 overexpression likely occurs after Glut1 overexpression. The appearance of Glut1 positive clones is associated with aggressive biologic behavior, which is worsened by the emergence of Glut3 positive clones. Glut1 and Glut3 are significant of poor prognosis indicators in cases of NSCLC. Cancer 1997; 80:1046-51. © 1997 American Cancer Society.read more
Citations
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A pathology atlas of the human cancer transcriptome
Mathias Uhlén,Mathias Uhlén,Cheng Zhang,Sunjae Lee,Evelina Sjöstedt,Evelina Sjöstedt,Linn Fagerberg,Gholamreza Bidkhori,Rui Benfeitas,Muhammad Arif,Zhengtao Liu,Fredrik Edfors,Kemal Sanli,Kalle von Feilitzen,Per Oksvold,Emma Lundberg,Sophia Hober,Peter Nilsson,Johanna Sofia Margareta Mattsson,Jochen M. Schwenk,Hans Brunnström,Bengt Glimelius,Tobias Sjöblom,Per-Henrik Edqvist,Dijana Djureinovic,Patrick Micke,Cecilia Lindskog,Adil Mardinoglu,Adil Mardinoglu,Fredrik Pontén +29 more
TL;DR: A Human Pathology Atlas has been created as part of the Human Protein Atlas program to explore the prognostic role of each protein-coding gene in 17 different cancers, and reveals that gene expression of individual tumors within a particular cancer varied considerably and could exceed the variation observed between distinct cancer types.
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Hypoxia in cancer: significance and impact on clinical outcome
Peter Vaupel,Arnulf Mayer +1 more
TL;DR: In this article, the authors suggest that hypoxia is prognostic for survival and local control in head and neck cancers, and use endogenous proteins (e.g., HIF-1α, GLUT-1, CA IX) or exogenous bioreductive drugs.
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GLUT1: A newly discovered immunohistochemical marker for juvenile hemangiomas
Paula E. North,Milton Waner,Milton Waner,Adam Mizeracki,Adam Mizeracki,Martin C. Mihm,Martin C. Mihm +6 more
TL;DR: It is reported here that high endothelial immunoreactivity for the erythrocyte-type glucose transporter protein GLUT1 is a specific feature of juvenile hemangiomas during all phases of these lesions.
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Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival
Jeffrey C. Rathmell,Casey J. Fox,David R. Plas,Peter S. Hammerman,Ryan M. Cinalli,Craig B. Thompson +5 more
TL;DR: Data indicate that Bax conformation is sensitive to glucose metabolism and that maintaining glucose uptake and phosphorylation can promote cell survival in the absence of growth factor.
Journal ArticleDOI
Prognostic Importance of the Standardized Uptake Value on 18F-Fluoro-2-Deoxy-Glucose–Positron Emission Tomography Scan in Non–Small-Cell Lung Cancer: An Analysis of 125 Cases
Johan Vansteenkiste,Sigrid Stroobants,Patrick Dupont,Paul De Leyn,Erik Verbeken,Georges Deneffe,Luc Mortelmans,Maurits Demedts +7 more
TL;DR: In this article, the authors analyzed the follow-up of 125 potentially operable non-small-cell lung cancer (NSCLC) patients, previously included in three prospective PET protocols, for their possible association with survival.
References
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Facilitative glucose transporters
TL;DR: This review summarizes recent advances concerning the structure, function, and regulation of the Glut proteins.
Journal ArticleDOI
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes
Jeffrey S. Flier,Jeffrey S. Flier,Michael M. Mueckler,Michael M. Mueckler,Patricia Usher,Harvey F. Lodish +5 more
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Overexpression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study
Raya S. Brown,Richard L. Wahl +1 more
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Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein
TL;DR: Data suggest that a genetically unrelated protein is responsible for hexose transport in normal liver, as mRNA from insulin-responsive and nonresponsive tissues are indistinguishable.
Journal ArticleDOI
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