Journal ArticleDOI
Oxidative 3α-hydroxysteroid dehydrogenase activity of human type 10 17β-hydroxysteroid dehydrogenase
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TLDR
The experimental results lead to the conclusion that mitochondrial 17β-HSD10 plays a significant part in a non-classical androgen synthesis pathway along with microsomal retinol dehydrogenases.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2003-11-01. It has received 51 citations till now. The article focuses on the topics: Retinol dehydrogenase & Dihydrotestosterone.read more
Citations
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Journal ArticleDOI
Integrated view on 17beta-hydroxysteroid dehydrogenases.
Gabriele Moeller,Jerzy Adamski +1 more
TL;DR: In this article, metabolic activities of 17β-HSDs are compared, their interplay with endogenous substrates summarised, and interlacing pathways depicted, and strategies on deciphering the physiological role of 17beta-HSD and the genetic predisposition for associated diseases are presented.
Journal ArticleDOI
Primary cell cultures as models of prostate cancer development.
TL;DR: Challenges that remain to be addressed if the full potential of primary cultures as a model system is to be realized include isolation, culture and characterization of stem cells, improved methodology to induce or maintain a fully differentiated, androgen-responsive phenotype, and identification of cell surface antigens or other markers with which to purify pure populations of live cancer or premalignant cells apart from non-malignant epithelial cells prior to culture.
Journal ArticleDOI
Activation of the Androgen Receptor by Intratumoral Bioconversion of Androstanediol to Dihydrotestosterone in Prostate Cancer
James L. Mohler,Mark Titus,Suxia Bai,Suxia Bai,Brian J. Kennerley,Fred B. Lih,Kenneth B. Tomer,Elizabeth M. Wilson +7 more
TL;DR: The ability to convert androstanediol to DHT provides a mechanism for optimal utilization of androgen precursors and catabolites for DHT synthesis.
Journal ArticleDOI
Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer
Amjad Khan,Laila M. Poisson,Vadiraja B. Bhat,Damian Fermin,Rong Zhao,Shanker Kalyana-Sundaram,George Michailidis,Alexey I. Nesvizhskii,Gilbert S. Omenn,Arul M. Chinnaiyan,Arun Sreekumar +10 more
TL;DR: In this article, the authors examined the proteomic alterations in a cohort of 15 prostate-derived tissues that included five each from adjacent benign prostate, clinically localized prostate cancer, and metastatic disease from distant sites.
Journal ArticleDOI
Design and validation of specific inhibitors of 17β-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis
TL;DR: Recent advances in the validation of these enzymes as targets for the treatment of steroid-dependent diseases, with emphasis on 17beta-HSD1, 3 and 5, the development of specific inhibitors, the models used for their evaluation, and their progress towards the clinic will be discussed.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
DNA sequencing with chain-terminating inhibitors
TL;DR: A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
Journal ArticleDOI
Short-chain dehydrogenases/reductases (SDR).
Hans Jörnvall,Bengt Persson,Maria Krook,Sílvia Atrian,Roser Gonzàlez-Duarte,Jonathan Jeffery,Debashis Ghosh +6 more
TL;DR: In the combined SDR superfamily, only one residue is strictly conserved and ascribed a crucial enzymatic function (Tyr 151 in the numbering system of human NAD(+)-linked prostaglandin dehydrogenase), and such a function is supported by chemical modifications, site-directed mutagenesis, and an active site position in those tertiary structures that have been characterized.
Journal ArticleDOI
Steroid 5 alpha-reductase: two genes/two enzymes.
David W. Russell,Jean D. Wilson +1 more
TL;DR: The structure of the determinants of apoptosis, a type of cell death, and the role that individual cells play in this process are studied.
Journal ArticleDOI
The redox state of free nicotinamide–adenine dinucleotide phosphate in the cytoplasm of rat liver
TL;DR: The application of the method of calculation to data published by Kraupp, Adler-Kastner, Niessner & Plank (1967), Goldberg, Passonneau & Lowry (1966) and Kauffman, Brown,passonneau and Lowry (1968) shows that the redox states of the NAD and NADP couples in cardiac-muscle cytoplasm and in mouse-brain cytop lasm are of the same order as those in rat liver.
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