Journal ArticleDOI
Oxysterols: novel biologic roles for the 21st century.
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TLDR
A major impetus for further inquiry is the recognition that in genetically determined errors in cholesterol synthesis such as Smith-Lemil-Opitz syndrome, the phenotypic effects on the developing fetus are not solely attributable to the lack of cholesterol but the accumulation of 7-dehydrocholesterol and its 27-hydroxy metabolite.About:
This article is published in Steroids.The article was published on 2008-02-01. It has received 87 citations till now. The article focuses on the topics: Oxysterol & CYP27A1.read more
Citations
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Free Radical Lipid Peroxidation: Mechanisms and Analysis
Journal ArticleDOI
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Jun Li,Blynn G. Bunney,Fan Meng,Megan Hastings Hagenauer,David M. Walsh,Marquis P. Vawter,Simon J. Evans,Prabhakara V. Choudary,Preston M. Cartagena,Jack D. Barchas,Alan F. Schatzberg,Edward G. Jones,Richard M. Myers,Stanley J. Watson,Huda Akil,William E. Bunney +15 more
TL;DR: A transcriptome-wide analysis of the human brain demonstrates a rhythmic rise and fall of gene expression in regions outside of the suprachiasmatic nucleus in control subjects, which suggests potentially important molecular targets for treatment of mood disorders.
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Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
Anne Vejux,Gérard Lizard +1 more
TL;DR: A substantial accumulation of polar lipids in cytoplasmic multilamellar structures was observed, demonstrating that cytotoxic oxysterols were phospholipidosis inducers, contributing to a better understanding of the associated pathologies, so that new treatments and drugs can be designed.
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Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins.
TL;DR: This work collectively allows ARMD lesion formation and its aftermath to be conceptualized as a response to the retention of a sub-endothelial apolipoprotein B lipoprotein, similar to a widely accepted model of atherosclerotic coronary artery disease (CAD).
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Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised
TL;DR: This review traces the evolution of the 'Oxysterol Hypothesis', which asserted that the suppressive effect of cholesterol on its own synthesis is mediated not by cholesterol itself, but by oxygenated forms of cholesterol, so called oxysterols.
References
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Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
TL;DR: It is reported that cholesterol is the lipophilic moiety covalently attached to the amino- terminal signaling domain during autoprocessing and that the carboxyl-terminal domain acts as an intramolecular cholesterol transferase.
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Virtual and biomolecular screening converge on a selective agonist for GPR30
Cristian Bologa,Chetana M. Revankar,Susan M. Young,Bruce S. Edwards,Jeffrey B. Arterburn,Alexander S. Kiselyov,Matthew A. Parker,Sergey E. Tkachenko,Nikolay P. Savchuck,Larry A. Sklar,Tudor I. Oprea,Eric R. Prossnitz +11 more
TL;DR: The identification of the first G PR30-specific agonist, G-1 (1), capable of activating GPR30 in a complex environment of classical and new estrogen receptors is described.
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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
TL;DR: It is concluded that the cloned cDNAs encode cholesterol 24-hydroxylases that synthesize oxysterols in neurons of the brain and that secretion of 24S-hydroxycholesterol from this tissue in the mouse is developmentally regulated.
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Biological activity of some oxygenated sterols
TL;DR: The ability of oxygenated sterols to inhibit sterol synthesis in cultured cells and the ineffectiveness of cholesterol under the same conditions suggest that feedback regulation of sterol biosynthesis may be brought about by an oxygenated steroid rather than by cholesterol.
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Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
TL;DR: It is shown that cholesterol or specific oxysterols are the critical products of sterol synthesis required for Shh pathway signal transduction in MB cells and that certain Oxysterols can maximally activate Shh target gene transcription through the Smoothened protein as effectively as the known Smo full agonist, SAG.